LY75/DEC-205 Antikörper

Produktnummer ABIN781804

Produktdetails anti-LY75/DEC-205 Antikörper

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LY75/DEC-205 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody recognizes CD205, an approx. 200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein-A affinity chromatography

Reinheit: > 95 % pure (by SDS-PAGE)

Immunogen: Recombinant Fc-tagged human CD205

Klon: HD30

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu LY75/DEC-205

Target: LY75/DEC-205 (LY75) (Lymphocyte Antigen 75 (LY75))

Andere Bezeichnung: CD205 / DEC-205 (LY75 Produkte)

Synonyme: LY75 antikoerper, MGC140308 antikoerper, DEC205 antikoerper, im:7150926 antikoerper, si:dkey-78p20.2 antikoerper, LYT75 antikoerper, CD205 antikoerper, DEC-205 antikoerper, CLEC13B antikoerper, GP200-MR6 antikoerper, LY-75 antikoerper, RGD1565962 antikoerper, Ly-75 antikoerper, lymphocyte antigen 75 antikoerper, CD205 protein antikoerper, CD302 antigen antikoerper, LY75 antikoerper, Cyan7822_2917 antikoerper, LY5 antikoerper, ly75 antikoerper, cd205 antikoerper, LOC100380704 antikoerper, LOC100433861 antikoerper, LOC100483541 antikoerper, Ly75 antikoerper

Hintergrund: CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells.Synonyms: C-type lectin domain family 13 member B, CLEC13B, DEC205, LY75, Lymphocyte antigen 75, gp200-MR6

Gen-ID: 100526664

NCBI Accession: NP_001185688

UniProt: O60449