ESR2 Antikörper (AA 512-530)

Produktnummer ABIN781661

Produktdetails anti-ESR2 Antikörper

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Bindungsspezifität: AA 512-530

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ESR2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: Monoclonal antibody 4ERβ-2D7 recognizes an epitope in the F region of the mouse and human Estrogen Receptor beta. The two different forms of the estrogen receptor, usually referred to as α and β, can form hormone-activated dimers, and, since the two forms are coexpressed in many cell types, the receptors may form ERα (αα) or ERβ (ββ) homodimers or ERαβ (αβ) heterodimers. Estrogen receptor alpha and beta show significant overall sequence homology, and both are composed of five domains (A-F domains listed from the N- to C-terminus). Antigen distribution: The antigen has been described in kidney, brain, bone, heart, lungs, intestinal mucosa, prostate, and endothelial cells. No cross-reactivity has been observedwith ER-alpha

Kreuzreaktivität (Details): Species reactivity (tested):Human and Mouse.

Aufreinigung: Affinity Chromatography

Immunogen: Peptide C512 to Q530 from murine ERbeta. Antigen: Estrogen Receptor beta. Epitope: Located in the F region.

Klon: ERbeta-2D7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore by adding 0.5 mL distilled water

Konzentration: 0.5 mg/mL

Buffer: Stock solution contains 0.5 mg/mL IgG, PBS, pH 7.2 with 5 mg/mL BSA as stabilizer and 0.01 % Kathon as a preservative.

Konservierungsmittel: Kathon CG

Vorsichtsmaßnahmen: This product contains Kathon CG a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the lyophilized antibody at 2- 8 °C. Following reconstitution, store at -20 °C.

Details zu ESR2

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Andere Bezeichnung: Estrogen Receptor beta (ESR2 Produkte)

Synonyme: ER-BETA antikoerper, ESR-BETA antikoerper, ESRB antikoerper, ESTRB antikoerper, Erb antikoerper, NR3A2 antikoerper, ER[b]1 antikoerper, zfER-beta1 antikoerper, zfER[b]1 antikoerper, erb2 antikoerper, CERB antikoerper, ERB antikoerper, erb antikoerper, esrb antikoerper, estrb antikoerper, nr3a2 antikoerper, ERbeta antikoerper, er-beta antikoerper, esr-beta antikoerper, ESR2 antikoerper, ERBETA antikoerper, er antikoerper, ER-beta antikoerper, ER[b] antikoerper, Estrb antikoerper, ER[b]2 antikoerper, ER[b]a antikoerper, zfER[b]2 antikoerper, zfER-beta2 antikoerper, Erb2 antikoerper, esr2 antikoerper, erbeta antikoerper, Esr2 antikoerper, ERBeta2 antikoerper, estrogen receptor 2 antikoerper, estrogen receptor 2b antikoerper, estrogen receptor beta 2 antikoerper, estrogen receptor 2 (beta) antikoerper, estrogen receptor 2a antikoerper, estrogen receptor beta antikoerper, ESR2 antikoerper, esr2b antikoerper, erb2 antikoerper, esr2 antikoerper, Esr2 antikoerper, esr2a antikoerper, erbeta antikoerper

Hintergrund: ER exists in two types: alpha and Beta. They are similar in structure. The ligand binding domain and the DNA binding domain are highly conserved in these proteins while the N-terminal transactivating domain is diverged considerably. Five isoforms of the hER beta gene, designated hER beta 1-5 have been identified. ERBeta binds to estrogen and activates genes through direct interaction with estrogen specific gene elements (ERE's). ER-Beta RNA has been detected in human thymus, spleen, ovary and testis and in rat ovary and prostrate. This tissue distribution overlaps but is not identical to that of ER - alphaRNA.Synonyms: ER-beta, ESR2, ESTRB, NR3A2, Nuclear receptor subfamily 3 group A member 2

Gen-ID: 2100

NCBI Accession: NP_001035365

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling