G Protein-Coupled Receptor 124 (GPR124) Antikörper (Biotin)

Antigen: G Protein-Coupled Receptor 124 (GPR124)

Synonyme: Tem5, mKIAA1531, 8430414O08Rik, 9530074E10Rik, MGC69043, si:dkey-208c22.2, TEM5, FLJ14390, KIAA1531, DKFZp434C211, DKFZp434J0911

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus), Schwein, Rind (Kuh), Hund

Konjugat: Biotin

Applikation: Western Blot (WB), ELISA, Immunpräzipitation (IP), Immunhistochemie (Paraffinschnitte) (IHC (p)), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)), Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN763153

Produktbeschreibung

Weitere Bezeichnung: GPR124

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human GPR124

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: TEM5, DKFZp434C211, DKFZp434J0911, FLJ14390, G protein coupled receptor 124, G-protein coupled receptor 124, GP124_HUMAN, GPR 124, GPR124, KIAA1531, TEM 5, TEM5, Tumor endothelial marker 5, Tumor endothelial marker 5 precursor.

Molekulargewicht: 139kDa

Kommentare:

Tumor endothelial markers (TEMs) display elevated expression during angiogenesis. Their associations with the cell surface membrane are of great interest for both biological and clinical research. G protein coupled receptor 124 (GPR124) is encoded as a seven pass transmembrane protein of 1331 amino acids and is most similar to the cadherin related Celsr1 proteins and members of the calcium independent alpha latrotoxin receptor family involved in transmitting signals across the cell membrane. GPCRs have been excellent drug targets because their natural ligands can often mimicked for agonistic or antagonistic purpose. The existence of tumour specific endothelial markers provides a resource for further understanding the mechanisms of tumour angiogenesis and encourages the development of antiangiogenic therapies in the future. ESTs for the gene that encodes GPR124 have been isolated primarily from amnion

connective tissue

ear

embryo

eye

ganglion

heart

lung

placenta

and skin libraries.

Anwendungen

Applikationshinweise: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Beschränkungen: Nur für Forschungszwecke einsetzbar