3/TP53I3 Antikörper (Gold)

Antigen: 3/TP53I3

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Konjugat: Gold

Applikation: Immunoelectron Microscopy (IEM)

Produktnummer: ABIN763054

Produktbeschreibung

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human PIG3/TP53I3

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: p53 induced gene 3 protein, p53-induced gene 3 protein, Putative quinone oxidoreductase, quinone oxidoreductase homolog, TP53I3, tumor protein p53 inducible protein 3, Tumor protein p53-inducible protein 3.

Molekulargewicht: 35kDa

Kommentare:

The protein encoded by this gene is similar to oxidoreductases

which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic

with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene (from EntrezGene).

Anwendungen

Applikationshinweise: Electron Microscopy (1:100-500)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Beschränkungen: Nur für Forschungszwecke einsetzbar