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Glucagon Receptor Antikörper (AA 11-110)

GCGR Reaktivität: Human, Ratte, Maus WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN751528
  • Target Alle Glucagon Receptor (GCGR) Antikörper anzeigen
    Glucagon Receptor (GCGR)
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 11-110
    Reaktivität
    • 55
    • 25
    • 24
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    Human, Ratte, Maus
    Wirt
    • 53
    • 1
    • 1
    Kaninchen
    Klonalität
    • 54
    • 1
    Polyklonal
    Konjugat
    • 21
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Glucagon Receptor Antikörper ist unkonjugiert
    Applikation
    • 40
    • 23
    • 17
    • 12
    • 12
    • 11
    • 7
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Pig,Chicken,Guinea Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Glucagon Receptor
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Rafacho, Gonçalves-Neto, Santos-Silva, Alonso-Magdalena, Merino, Taboga, Carneiro, Boschero, Nadal, Quesada: "Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats." in: PLoS ONE, Vol. 9, Issue 4, pp. e93531, (2014) (PubMed).

  • Target
    Glucagon Receptor (GCGR)
    Andere Bezeichnung
    Glucagon Receptor (GCGR Produkte)
    Synonyme
    GCGR antikoerper, GGR antikoerper, GR antikoerper, glucagon receptor antikoerper, GCGR antikoerper, Gcgr antikoerper
    Hintergrund

    Synonyms: GGR, GL-R, Glucagon receptor, GCGR

    Background: G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.

    Gen-ID
    2642
    UniProt
    P47871
    Pathways
    Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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