DIO3 Antikörper (AA 51-150)

Produktnummer ABIN750883

Produktdetails anti-DIO3 Antikörper

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Bindungsspezifität: AA 51-150

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIO3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Dio3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu DIO3

Target: DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))

Andere Bezeichnung: Dio3 (DIO3 Produkte)

Synonyme: 5DIII antikoerper, DIOIII antikoerper, txdi3 antikoerper, dioiii antikoerper, XL-15 antikoerper, itdi3 antikoerper, D3 antikoerper, TXDI3 antikoerper, iodothyronine deiodinase 3 antikoerper, deiodinase, iodothyronine, type 3 antikoerper, deiodinase, iodothyronine, type III antikoerper, deiodinase, iodothyronine type III antikoerper, deiodinase, iodothyronine, type 3 L homeolog antikoerper, DIO3 antikoerper, dio3 antikoerper, Dio3 antikoerper, dio3.L antikoerper

Hintergrund:

Synonyms: Type 3 DI, D3, 5DIII, Deiodinase iodothyronine type 3, Deiodinase iodothyronine type III, Dio 3, DIOIII, MGC124117, MGC124118, TXDI3, Type III 5' deiodinase, Type III iodothyronine deiodinase, IOD3_HUMAN.

Background: Dio3 belongs to the iodothyronine deiodinase family. It has an essential role for regulation of thyroid hormone inactivation during embryological development in that it catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. Dio3 may play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones and has been linked to the development of consumptive hypothyroidism in both infants and adults.

Gen-ID: 1735

Pathways: Hormone Activity