Angiotensin III (AGT3) Antikörper

Antigen: Angiotensin III (AGT3)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus), Pferd

Applikation: Western Blot (WB), ELISA, Immunpräzipitation (IP), Immunhistochemie (Paraffinschnitte) (IHC (p)), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)), Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN750508

Produktbeschreibung

Weitere Bezeichnung: Angiotensin III

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human Angiotensin III

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Synonym: Ang III, Angiotensin 3, Angiotensin3, Angiotensin 3, Angiotensinogen, ANHU, SERPINA8.

Kommentare:

Angiotensin III is an eptapeptide drived from cleavage of full length angiotensin (AGT). AGT is a polypeptide vasopressor hormone formed by the catalytic action of renin

which is released mainly by the kidneys in response to low blood volume or low sodium content in the body. The juxtaglomerular cells release renin when juxtaglomerular apparatus decreases in the kidneys. Renin (called angiotensinogenase) is an enzyme of the hydrolase class that catalyzes cleavage of the leucine leucine bond in angiotensinogen (a serum globulin) to generate angiotensin I in the liver. Angiotensin I acts mainly as a precursor to angiotensin II

which is a vasopressor and stimulator of aldosterone secretion by the adrenal cortex

and also functions as a neurotransmitter. Angiotensin III (heptapeptide) is a degradation product of angiotensin II

and has less vasopressor activity than the parent compound. However

Angiotensin III does stimulate aldosterone release.

Anwendungen

Applikationshinweise: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: affinity purified by Protein A

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Krebs, Endokrines System

Beschränkungen: Nur für Forschungszwecke einsetzbar