MCSF Receptor (AA 200-245) Antikörper (Cy5.5)

Details zu Produkt Nr. ABIN750148, Anbieter: Anmelden zum Anzeigen
Antigen
Epitop
AA 200-245
15
15
15
12
6
2
2
2
2
2
2
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
82
62
62
Wirt
Kaninchen
82
Klonalität
Polyklonal
Konjugat
Cy5.5
4
4
4
4
4
4
4
4
4
4
3
3
3
3
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
49
33
13
12
11
3
2
1
Optionen
Hersteller
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Immunogen KLH conjugated synthetic peptide derived from human MCSF receptor
Isotyp IgG
Reinigung Purified by Protein A.
Hintergrund

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Subcellular location: Extracellular

Synonyms: FMS, CSFR, FIM2, HDLS, C-FMS, CD115, CSF-1R, M-CSF-R, Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor, CSF-1-R, Proto-oncogene c-Fms, CSF1R

Gen-ID 1436
UniProt P07333
Forschungsgebiet Signaling, Innate Immunity, Cytokines, Angiogenesis, Stem Cells
Applikationshinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
Produkt verwendet in: Gorden, Saha, Khammanivong, Schwartz, Dickerson: "Lysosomal drug sequestration as a mechanism of drug resistance in vascular sarcoma cells marked by high CSF-1R expression." in: Vascular cell, Vol. 6, pp. 20, 2014 (PubMed).

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