Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 155-205), (Tyr185), (pThr183) Antikörper

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Antigen
  • erk1/2
  • mitogen-activated protein kinase
  • erk1/2
Epitop
AA 155-205, Tyr185, pThr183
122
120
30
29
29
19
17
15
15
15
15
14
12
9
9
9
9
8
6
5
4
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
410
310
294
57
22
15
8
8
7
7
7
6
5
5
3
2
2
2
1
1
1
1
1
Wirt
Kaninchen
338
77
7
Klonalität
Polyklonal
Konjugat
Unkonjugiert
12
11
11
9
7
7
7
7
6
6
6
6
6
6
2
2
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
295
109
83
77
59
56
42
38
14
10
6
4
2
2
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic phosphopeptide derived from human ERK2 around the phosphorylation site of Thr183/Tyr185
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung Erk1+Erk2 (MAPK1/3 Antibody Abstract)
Sub Type Cocktail
Hintergrund

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Subcellular location: Cytoplasm

Synonyms: ERK, p38, p4, p41, ERK2, ERT1, ERK-2, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, p42-MAPK, ERK1, ERT2, ERK-1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A, p44-ERK1, p44-MAPK, Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1, Extracellular signal-regulated kinase 2, MAP kinase isoform p42, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, MAPK1

Gen-ID 5594, 5595
UniProt P28482
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
SDS-PAGE (SDS) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 155-205), (Tyr185), (pThr183) antibody (ABIN732458) Lane 1: mouse heart lysates Lane 2: mouse S/P20 cell lysates probed with Anti phospho...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 155-205), (Tyr185), (pThr183) antibody (ABIN732458) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-phospho-E...
Produkt verwendet in: Hirata, Katayama, Tsuji, Imura, Natsume, Sugahara, Kunieda, Nakamura, Otsuki: "Homeobox family Hoxc localization during murine palate formation." in: Congenital anomalies, Vol. 56, Issue 4, pp. 172-9, 2016 (PubMed).

Iriyama, Hatta, Takei: "Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes." in: Cancer medicine, Vol. 5, Issue 11, pp. 3223-3234, 2016 (PubMed).

Wang, Fu, Jiang, Yu, Wang, Han, Liu, Wang: "Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia." in: Behavioural brain research, Vol. 265, pp. 171-80, 2014 (PubMed).

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