DNMT3B Antikörper (DNA (Cytosine-5-)-Methyltransferase 3 beta) (AA 1-50)

Details for Product anti-DNMT3B Antibody No. ABIN727623, Anbieter: Anmelden zum Anzeigen
Antigen
  • cb633
  • dnmt3b
  • DNMT3B
  • LOC100218113
  • ICF
  • ICF1
  • M.HsaIIIB
  • cb91
  • dnmt3bl
  • dnmt7
  • sb:cb91
  • wu:fb16h07
  • MmuIIIB
  • DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1
  • DNA methyltransferase 3 beta
  • microtubule associated protein RP/EB family member 1
  • DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
  • DNA methyltransferase 3B
  • dnmt3bb.1
  • DNMT3B
  • MAPRE1
  • dnmt3b
  • dnmt3ba
  • Dnmt3b
Epitop
AA 1-50
16
14
10
7
6
4
4
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
124
62
26
4
2
2
2
2
2
2
2
1
1
1
Wirt
Kaninchen
88
38
2
2
2
Klonalität
Polyklonal
Konjugat
Dieser DNMT3B Antikörper ist unkonjugiert
4
4
4
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
112
48
41
38
34
34
24
16
15
12
10
3
3
3
2
2
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH conjugated synthetic peptide derived from human Dnmt3 Beta
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung Dnmt3 beta (DNMT3B Antibody Abstract)
Hintergrund

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

Subcellular location: Nucleus

Synonyms: ICF, ICF1, M.HsaIIIB, DNA (cytosine-5)-methyltransferase 3B, Dnmt3b, DNA methyltransferase HsaIIIB, DNA MTase HsaIIIB

Gen-ID 1789
UniProt Q9UBC3
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-50) antibody (ABIN727623) Formalin-fixed and paraffin embedded: human colon cancer tissue labeled with Anti-Dnm...
Immunohistochemistry (IHC) image for anti-DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B) (AA 1-50) antibody (ABIN727623) Formalin-fixed and paraffin embedded: rat spinal cord tissue labeled with Anti-Dnmt-3...
Produkt verwendet in: Wu, Bu, Yu, Li, Huang, Meng, Zhang, Ma, Li: "Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis." in: Toxicology and applied pharmacology, Vol. 315, pp. 35-49, 2016 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)).

Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: "Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation." in: Neurobiology of disease, Vol. 82, pp. 54-65, 2015 (PubMed).

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