Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Antikörper (PE)

Antigen: Apoptotic Chromatin Condensation Inducer 1 (ACIN1)

Synonyme: ACN, ACINUS, fSAP152, KIAA0670, DKFZp667N107, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn, MGC69430, MGC132201

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus), Rind (Kuh), Pferd, Hund

Konjugat: PE

Applikation: Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN725280

Produktbeschreibung

Weitere Bezeichnung: Acinus

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human Acinus

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: ACIN 1, ACIN1, ACINUS, CAN, Apoptotic chromatin condensation inducer 1, Apoptotic chromatin condensation inducer in the nucleus, DKFZp667N107, KIAA0670.

Spezifität: Excitation / Emission Wavelengths: 565nm/578nm

Molekulargewicht: 67kDa

Kommentare:

Chromatin condensation and nuclear fragmentation (CCNF) are the hallmarks of apoptosis. CCNF is triggered by the activation of members of the caspase family

caspase activated DNase (CAD/DFF40)

and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by Caspase 3 and an additional unknown protease generating a small active peptide p17

which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated Acinus L (1341 amino acids)

Acinus S (583 amino acids) and Acinus S' (614 amino acids)

Synonyme: ACN, ACINUS, fSAP152, KIAA0670, DKFZp667N107, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn, MGC69430, MGC132201

Anwendungen

Applikationshinweise: Flow-Cyt (1:50-200), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Krebs, Apoptose/Nekrose, Zellzyklus

Beschränkungen: Nur für Forschungszwecke einsetzbar