APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Antikörper (HRP)

Antigen: APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2)

Synonyme: APE2, XTH2, APEXL2, ape2, xth2, apexl2, MGC79651, MGC55889, zgc:55889, apex2, MGC82216, APEX2

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Konjugat: HRP

Applikation: Western Blot (WB), ELISA

Produktnummer: ABIN718490

Produktbeschreibung

Weitere Bezeichnung: APEX2

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from hu APEX2

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: AP endonuclease 2, AP endonuclease XTH2, APE 2, APE2, APEX 2, APEX L2, APEX nuclease (apurinic/apyrimidinic endonuclease) 2, APEX Nuclease 2, APEX nuclease like 2, APEXL 2, APEXL2, Apurinic apyrimidinic endonuclease 2, Apurinic/apyrimidinic endonuclease 2, Apurinic/apyrimidinic endonuclease like 2, C430040P13Rik, DNA (apurinic or apyrimidinic site) lyase 2, XTH 2, XTH2.

Molekulargewicht: 54-57kDa

Kommentare:

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis

by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).

Anwendungen

Applikationshinweise: WB (1:200-1000), ELISA (1:500-1000)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Chromatin und nukleäre Signaltransduktion, DNS/RNS

Beschränkungen: Nur für Forschungszwecke einsetzbar