MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1)

Details for Product anti-MAPK8IP1 Antibody No. ABIN716441, Anbieter: Anmelden zum Anzeigen
Antigen
  • IB1
  • JIP-1
  • Jip1
  • Prkm8ip
  • Skip
  • mjip-2a
  • JIP1
  • Jip-1
  • Mapk8ip
  • PRKM8IP
  • mitogen-activated protein kinase 8 interacting protein 1
  • MAPK8IP1
  • LOC100344706
  • Mapk8ip1
Reaktivität
Human, Maus, Ratte (Rattus)
66
45
39
Wirt
Kaninchen
69
2
1
Klonalität
Polyklonal
Konjugat
Dieser MAPK8IP1 Antikörper ist unkonjugiert
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
56
31
17
12
8
7
4
3
2
2
1
Optionen
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Immunogen KLH conjugated synthetic peptide derived from human JIP1/MAPK8IP1
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung Mapk8ip1 (MAPK8IP1 Antibody Abstract)
Hintergrund

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.

Subcellular location: Cytoplasm

Synonyms: IB1, JIP1, JIP-1, PRKM8IP, C-Jun-amino-terminal kinase-interacting protein 1, JNK-interacting protein 1, Islet-brain 1, IB-1, JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1, MAPK8IP1

Gen-ID 9479
UniProt Q9UQF2
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-MAPK8IP1 Antikörper (Mitogen-Activated Protein Kinase 8 Interacting Protein 1) (ABIN716441) Formalin-fixed and paraffin embedded rat brain labeled with Anti-MAPK8IP1 Polyclonal ...