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Prominin 2 Antikörper (AA 301-400)

PROM2 Reaktivität: Human WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN715151
  • Target Alle Prominin 2 (PROM2) Antikörper anzeigen
    Prominin 2 (PROM2)
    Bindungsspezifität
    • 15
    • 8
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    AA 301-400
    Reaktivität
    • 38
    • 5
    • 4
    • 1
    • 1
    Human
    Wirt
    • 37
    • 1
    Kaninchen
    Klonalität
    • 37
    • 1
    Polyklonal
    Konjugat
    • 11
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Prominin 2 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 19
    • 13
    • 12
    • 12
    • 5
    • 4
    • 4
    • 2
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Prominin 2
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Turco, Lam, Rule, Denic, Lieske, Miller, Larson, Kremers, Jayachandran: "Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys." in: Journal of extracellular vesicles, Vol. 5, pp. 29642, (2016) (PubMed).

    Jayachandran, Lugo, Heiling, Miller, Rule, Lieske: "Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study." in: Biology of sex differences, Vol. 6, pp. 2, (2015) (PubMed).

  • Target
    Prominin 2 (PROM2)
    Andere Bezeichnung
    Prominin 2 (PROM2 Produkte)
    Synonyme
    PROML2 antikoerper, Prom-rp antikoerper, Promrp antikoerper, Trprp antikoerper, AI507243 antikoerper, PROM2 antikoerper, prom3 antikoerper, proml3 antikoerper, fd36c02 antikoerper, fo25d03 antikoerper, wu:fd36c02 antikoerper, prom-2 antikoerper, prominin 2 antikoerper, prominin 2 L homeolog antikoerper, PROM2 antikoerper, Prom2 antikoerper, prom2 antikoerper, prom2.L antikoerper
    Hintergrund

    Synonyms: PROML2, Prominin-2, PROM-2, Prominin-like protein 2, hPROML2, PROM2, UNQ2521/PRO6014

    Background: Prominin 2 is a 112 kDa glycoporotein structurally related to Prominin 1 (CD133) although amino acid similarity is not more than 30 % , but their genomic organization is strikingly similar. Like Prominin 1, the prominin 2 exhibit similar membrane topology with 5 trans-membrane domains and two large glycosylated extracellular domains. Similar to Prominin1 localization, the Prominin 2 is also associated with membrane protrusions of the epithelial cells from adult kidney, and all along the digestive track and other epithelial tissues.Prominin 2 expression is down-regulated in aggressive prostate cancer cell lines and transient transfection of PROML2 expression vectors has been shown to induce apoptosis in cultured prostate cancer cells, suggesting a tumor suppressive role for Prominin 2. Prominin 2 expression is likely to be involved in growth suppression in the prostate, and down-regulation of Prominin 2 may disrupt normal prostatic homeostasis and lead to uncontrolled prostatic growth.

    Gen-ID
    150696
    UniProt
    Q8N271
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