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Tuberin Antikörper (AA 1601-1750)

Name: Tuberin Antikörper (AA 1601-1750)
SKU: ABIN701200
Price: 384.62 EUR
Availability: InStock

TSC2 Reaktivität: Human, Maus, Ratte ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

Formalin-fixed and paraffin embedded human endometrial tissue labeled with Anti-Tuberin/TSC2 Polyclonal Antibody, Unconjugated (ABIN701200) at 1:300, followed by conjugation to the secondary antibody and DAB staining

IHC

Formalin-fixed and paraffin embedded human gastric adenocarcinoma tissue labeled with Anti-Tuberin/TSC2 Polyclonal Antibody, Unconjugated (ABIN701200) at 1:300, followed by conjugation to the secondary antibody and DAB staining

IHC

Formalin-fixed and paraffin embedded rat brain tissue labeled withAnti-Tuberin/TSC2 Polyclonal Antibody, Unconjugated (ABIN701200) at 1:200, followed by conjugation to the secondary antibody and DAB staining

IHC

3 Abbildungen

(1 reference)

Produktnummer ABIN701200

Datenblatt (PDF)

Target Alle Tuberin (TSC2) Antikörper anzeigen

Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
Bindungsspezifität
29

22

20

19

16

16

15

15

14

13

12

11

11

10

9

8

8

7

7

7

7

7

7

7

7

7

7

7

6

6

6

5

5

5

4

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
AA 1601-1750
Reaktivität
290

194

123

8

6

2

2

1

1

1

1

1
Human, Maus, Ratte
Wirt
382

12
Kaninchen
Passende Sekundärantikörper
Klonalität
374

20
Polyklonal
Konjugat
143

35

33

31

24

24

11

11

11

11

10

10

7

7

7

7

7

1

1

1

1

1
Dieser Tuberin Antikörper ist unkonjugiert
Applikation
211

183

125

80

79

66

36

33

19

12

8

7

6

4

2
ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität

Human, Maus, Ratte

Homologie

Dog,Cow,Pig,Horse,Rabbit

Aufreinigung

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from human Tuberin

Isotyp

IgG

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TSC2 Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB13393 unconjugated

anti-Tuberous Sclerosis 2 (TSC2) (AA 1611-1807) antibody
TSC2 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

anti-Tuberous Sclerosis 2 (TSC2) (AA 1776-1805) antibody
TSC2 Reaktivität: Human ELISA, WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Tuberous Sclerosis 2 (TSC2) (pSer1387) antibody
TSC2 Reaktivität: Human DB, IF Wirt: Kaninchen Polyclonal RB11388 unconjugated

anti-Tuberous Sclerosis 2 (TSC2) (AA 1397-1426) antibody
TSC2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB42388 unconjugated

anti-Tuberous Sclerosis 2 (TSC2) antibody
TSC2 Reaktivität: Human, Maus, Ratte IHC Wirt: Kaninchen Polyclonal unconjugated

anti-Tuberous Sclerosis 2 (TSC2) (Ser1798) antibody
TSC2 Reaktivität: Human ELISA, WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

anti-Tuberous Sclerosis 2 (TSC2) (pThr1462) antibody
TSC2 Reaktivität: Human, Maus, Ratte ELISA, WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Tuberous Sclerosis 2 (TSC2) (AA 900-1150) antibody
TSC2 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Tuberous Sclerosis 2 (TSC2) (AA 1396-1496) antibody
TSC2 Reaktivität: Human ELISA, WB, IF Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel

ProClin

Vorsichtsmaßnahmen

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit

12 months
Wang, Chen, Deng, Bian, Huang, Lei, Lv, Liu, Li: "Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation." in: International journal of biological macromolecules, Vol. 96, pp. 578-588, (2017) (PubMed).
Target

Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Andere Bezeichnung

Tuberin (TSC2 Produkte)

Hintergrund

Synonyms: LAM, TSC4, PPP1R160, Tuberin, Tuberous sclerosis 2 protein, TSC2
Background: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Gen-ID

7249

UniProt

P49815

Pathways

RTK Signalweg, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus