Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42) Antikörper (Biotin)

Antigen: Cell Division Cycle 42 (GTP Binding Protein, 25kDa) (CDC42)

Synonyme: G25K, CDC42Hs, AI747189, AU018915, CDC42, MGC128612, Cdc42, MGC86687, zgc:55427, zgc:86687, wu:fi33d02, cdc42, g25k, Xcdc42, cdc42hs, MGC79526, LOC100227983

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Ratte (Rattus), Maus

Konjugat: Biotin

Applikation: Western Blot (WB), ELISA, Immunpräzipitation (IP), Immunhistochemie (Paraffinschnitte) (IHC (p)), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)), Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN700737

Produktbeschreibung

Weitere Bezeichnung: CDC42

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human CDC42/Cell division cycle 42

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: CDC 42, CDC42Hs, Cell division control protein 42 homolog, Cell division cycle 42, Cell division cycle 42 isoform 1, Cell division cycle 42 isoform 2, dJ224A6.1.1, dJ224A6.1.2, G25K, G25K GTP binding protein, Growth regulating protein, GTP binding protein 25kD, Small GTP binding protein CDC42.

Molekulargewicht: 25kDa

Kommentare:

CDC42 is a small GTPase of the Rho subfamily

which regulates signaling pathways that control diverse cellular functions including cell morphology

migration

endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc42

and is able to complement the yeast cdc42 1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott Aldrich syndrome protein (NWASP)

which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in at least two transcript variants.

Anwendungen

Applikationshinweise: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Krebs, Zellzyklus, Kinasen/Phosphatasen

Beschränkungen: Nur für Forschungszwecke einsetzbar