G Protein-Coupled Estrogen Receptor 1 (GPER) Antikörper (Gold)

Antigen: G Protein-Coupled Estrogen Receptor 1 (GPER)

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus), Kaninchen, Huhn, Pferd, Rind (Kuh)

Konjugat: Gold

Applikation: Immunoelectron Microscopy (IEM)

Produktnummer: ABIN685725

Produktbeschreibung

Weitere Bezeichnung: GPR30

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human GPR30 C-terminus

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: G Protein Coupled Receptor 30, G-protein coupled estrogen receptor 1, Membrane estrogen receptor, mER, Chemokine receptor-like 2, IL8-related receptor DRY12, Flow-induced endothelial G-protein coupled receptor 1, FEG-1, Lymphocyte-derived G-protein coupled receptor, LYGPR, GPCR-BR, CEPR, CMKRL2, DRY12, GPER.

Molekulargewicht: 42kDa

Kommentare:

G protein-coupled receptors (GPRs

or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone

endogenous peptide

and neurotransmitter signals into intracellular effects via G proteins. GRP30 is a member of this family and is an orphan receptor. GPR30 expression has been reported in brain

breast carcinoma

blood

bone marrow

CNS

heart

liver

lung

lymph node

placenta

and spleen. In brain

GPR30 is expressed as a 2.8 kb transcript in basal forebrain

frontal cortex

thalamus

hippocampus

caudate and putamen. However

unlike other known G protein-coupled receptors

GPR30 localizes to the endoplasmic reticulum

where it specifically binds estrogen and estrogen derivatives.

Anwendungen

Applikationshinweise: Electron Microscopy (1:100-500)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Beschränkungen: Nur für Forschungszwecke einsetzbar