Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 196-210), (pThr202), (pTyr204) Antikörper

Details zu Produkt Nr. ABIN682933, Anbieter: Anmelden zum Anzeigen
Antigen
  • erk1/2
  • mitogen-activated protein kinase
  • erk1/2
Epitop
pThr202, pTyr204, AA 196-210
114
103
30
30
28
19
18
17
15
15
15
15
14
12
9
9
9
8
7
7
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus), Rind (Kuh)
403
312
300
56
24
15
9
8
8
8
7
6
5
5
3
3
2
2
2
1
1
1
1
Wirt
Kaninchen
331
76
6
Klonalität
Polyklonal
Konjugat
Unkonjugiert
12
11
11
9
7
7
7
6
6
6
6
6
6
6
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
291
106
81
77
60
54
39
38
14
10
6
4
3
2
2
2
2
Optionen
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Immunogen KLH conjugated synthetic phosphopeptide derived from human p44/42 MAPK around the phosphorylation site of (Thr202/Tyr204)
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung Erk1/2 (MAPK1/3 Antibody Abstract)
Sub Type Cocktail
Hintergrund

p44/42 MAP Kinase(Thr202), ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.

Subcellular location: Cytoplasm, Nucleus

Synonyms: ERK1, ERT2, ERK-1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A, p44-ERK1, p44-MAPK, Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, Microtubule-associated protein 2 kinase, MAPK3

Gen-ID 5595
UniProt P27361
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
SDS-PAGE (SDS) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 196-210), (pThr202), (pTyr204) Antikörper (ABIN682933) Lane 1: human colon carcinoma lysates probed with Anti phospho-ERK1/2(Thr202 + Tyr204...
Immunohistochemistry (IHC) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 196-210), (pThr202), (pTyr204) Antikörper (ABIN682933) Formalin-fixed and paraffin embedded human liver labeled with Anti-phospho-ERK1/2(Thr...
Immunofluorescence (IF) image for anti-Mitogen-Activated Protein Kinase 1/3 (MAPK1/3) (AA 196-210), (pThr202), (pTyr204) Antikörper (ABIN682933) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-phospho-E...
Produkt verwendet in: Wang, Chen, Tang, Jiang, Ji: "AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis." in: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Vol. 74, Issue 5, pp. 927.e1-927.e13, 2016 (PubMed).

Liu, Jiang, Zhang, Li, Li, Xie, Hu: "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 192, 2016 (PubMed).

Liu, Huang, Wang, Song, Cen, Ji: "Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway." in: Chemico-biological interactions, Vol. 262, pp. 1-11, 2016 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Rat (Rattus)).

Geng, Zhu, Xie, Li, Wu, Liang, Xie, Zhu, Huang, Zhu, Wu, Zhong: "Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice." in: European journal of nutrition, 2015 (PubMed).

Chen, Bao, Chen, Burton, Gong, Gu, Mi, Bao: "Mycobacterium tuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses." in: Medical microbiology and immunology, 2015 (PubMed).

Rosenzweig, Ou, Quinn: "P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture." in: Journal of cellular and molecular medicine, Vol. 17, Issue 4, pp. 508-17, 2013 (PubMed).