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ERK1/2 Antikörper (pThr202, pTyr204)

MAPK1/3 Reaktivität: Human, Maus, Ratte, Rind (Kuh) WB, ELISA, IHC (p), IF (cc), FACS, IF (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN682933
  • Target Alle ERK1/2 (MAPK1/3) Antikörper anzeigen
    ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
    Bindungsspezifität
    • 55
    • 40
    • 30
    • 30
    • 16
    • 12
    • 12
    • 10
    • 8
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr202, pTyr204
    Reaktivität
    • 199
    • 169
    • 166
    • 23
    • 22
    • 18
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh)
    Wirt
    • 143
    • 58
    • 4
    Kaninchen
    Klonalität
    • 139
    • 66
    Polyklonal
    Konjugat
    • 99
    • 12
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Dieser ERK1/2 Antikörper ist unkonjugiert
    Applikation
    • 157
    • 64
    • 50
    • 50
    • 49
    • 37
    • 25
    • 23
    • 22
    • 12
    • 7
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Kreuzreaktivität
    Hund, Human, Maus, Ratte
    Homologie
    Cow,Pig,Horse,Chicken,Rabbit,Guinea Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human p44/42 MAPK around the phosphorylation site of (Thr202/Tyr204)
    Isotyp
    IgG
    Top Product
    Discover our top product MAPK1/3 Primärantikörper
  • Applikationshinweise
    WB 1:100-1000
    IHC-P 1:100-500
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Jeon, Han, Lee, Park, Kim, Yoo, Lee: "Activation of the complement system in an osteosarcoma cell line promotes angiogenesis through enhanced production of growth factors." in: Scientific reports, Vol. 8, Issue 1, pp. 5415, (2019) (PubMed).

    Zhang, Liu, Wang, Xie, Sheng, Zhang, Yuan, Han, Weng: "Seasonal Expression of Oxytocin and Oxytocin Receptor in the Scented Gland of Male Muskrat (Ondatra zibethicus)." in: Scientific reports, Vol. 7, Issue 1, pp. 16627, (2018) (PubMed).

    Zheng, Wang, Zou, Jing, Yang, Li, Wang: "Ginsenoside Rb1 improves cardiac function and remodeling in heart failure." in: Experimental animals, Vol. 66, Issue 3, pp. 217-228, (2017) (PubMed).

    Wang, Chen, Tang, Jiang, Ji: "AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis." in: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, Vol. 74, Issue 5, pp. 927.e1-927.e13, (2016) (PubMed).

    Liu, Jiang, Zhang, Li, Li, Xie, Hu: "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 192, (2016) (PubMed).

    Liu, Huang, Wang, Song, Cen, Ji: "Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway." in: Chemico-biological interactions, Vol. 262, pp. 1-11, (2016) (PubMed).

    Chen, Shi, Li, Deng, Zhang: "Downregulation of MACC1 expression enhances cisplatin sensitivity in SKOV-3/DDP cells." in: Genetics and molecular research : GMR, Vol. 14, Issue 4, pp. 17134-44, (2016) (PubMed).

    Geng, Zhu, Xie, Li, Wu, Liang, Xie, Zhu, Huang, Zhu, Wu, Zhong: "Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice." in: European journal of nutrition, (2015) (PubMed).

    Chen, Bao, Chen, Burton, Gong, Gu, Mi, Bao: "Mycobacterium tuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses." in: Medical microbiology and immunology, (2015) (PubMed).

    Xing, He, Yu, Hou, Chen: "Increased expression of receptor for advanced glycation end-products worsens focal brain ischemia in diabetic rats." in: Neural regeneration research, Vol. 7, Issue 13, pp. 1000-5, (2015) (PubMed).

    Rosenzweig, Ou, Quinn: "P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture." in: Journal of cellular and molecular medicine, Vol. 17, Issue 4, pp. 508-17, (2013) (PubMed).

  • Target
    ERK1/2 (MAPK1/3) (Mitogen-Activated Protein Kinase 1/3 (MAPK1/3))
    Andere Bezeichnung
    Erk1/2 (MAPK1/3 Produkte)
    Synonyme
    erk1/2 antikoerper, mitogen-activated protein kinase antikoerper, erk1/2 antikoerper
    Sub Type
    Cocktail
    Hintergrund

    Synonyms: ERK1, ERT2, ERK-1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A, p44-ERK1, p44-MAPK, Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase isoform p44, Microtubule-associated protein 2 kinase, MAPK3

    Background: p44/42 MAP Kinase(Thr202), ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.

    Gen-ID
    5595
    UniProt
    P27361
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