5-HTR4 Antikörper (Gold)

Antigen: 5-HTR4

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Ratte (Rattus), Maus, Rind (Kuh)

Konjugat: Gold

Applikation: Immunoelectron Microscopy (IEM)

Produktnummer: ABIN677836

Produktbeschreibung

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human 5-HTR4 N -terminus

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: 5-HTR4 (5-hydroxytryptamine (serotonin) receptor 4a), Htr4a, 5-HT4, 5-HT4A, 5HT4, Htr45 HT 4, 5 HT4, 5 HT4R, 5 hydroxytryptamine 4 receptor, 5 hydroxytryptamine receptor 4, 5 hydroxytryptamine serotonin receptor 4, 5 hydroxytryptamine4 receptor, 5HT4, 5HT4R, Cardiac 5 HT4 receptor, HTR 4, HTR4,Serotonin 5 HT4 receptor, Serotonin receptor 4.

Molekulargewicht: 43kDa

Kommentare:

The 5HT4 Receptor is one of the several different receptors for 5- hydroxytryptamine (serotonin)

a biogenic hormone that functions as a neurotransmitter

a hormone

and a mitogen. The activity of this receptor is mediated by G proteins that stimulates adenylate cyclase. 5HT4a receptors may play a role in opioid-induced respiratory depression. [SUBCELLULAR LOCATION] Cell membrane

Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes

while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions

such as microvilli[TISSUE SPECIFICITY] Isoform 5-HT4(A) is expressed in ileum

brain

and atrium

but not in the ventricle. [SIMILARITY] Belongs to the G-protein coupled receptor 1 family.

Anwendungen

Applikationshinweise: Electron Microscopy (1:100-500)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Beschränkungen: Nur für Forschungszwecke einsetzbar