Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1) Antikörper (PE)

Antigen: Secretoglobin, Family 1A, Member 1 (Uteroglobin) (SCGB1A1)

Synonyme: UGL, SCGB1A1, UGB, CC10, CC16, CCSP

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Konjugat: PE

Applikation: Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN675573

Produktbeschreibung

Weitere Bezeichnung: Uteroglobin

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human Uteroglobin

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: secretoglobin, family 1A, member 1, Scgb1a1, CC10, CC16, CCSP, PCB-BP, UG, UGB, Utg.

Spezifität: Excitation / Emission Wavelengths: 565nm/578nm

Molekulargewicht: 10kDa

Kommentare:

Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity

as well as

a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum

its increase is associated with age

asbestos

nitrogen chloride and ozone exposure

sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection

in silica-exposed workers

smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia

diabetic fetopathy

Turner and Down syndrome). In pleural effusions

the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.

Anwendungen

Applikationshinweise: Flow-Cyt (1:50-200), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Beschränkungen: Nur für Forschungszwecke einsetzbar