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CCL5 Antikörper (AA 62-91)

CCL5 Reaktivität: Human, Maus, Meerschweinchen, Schwein ELISA, IHC (p), IF (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN674949
  • Target Alle CCL5 Antikörper anzeigen
    CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))
    Bindungsspezifität
    • 38
    • 14
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 62-91
    Reaktivität
    • 78
    • 42
    • 19
    • 18
    • 15
    • 15
    • 9
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Human, Maus, Meerschweinchen, Schwein
    Wirt
    • 105
    • 29
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 99
    • 38
    Polyklonal
    Konjugat
    • 67
    • 30
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CCL5 Antikörper ist unkonjugiert
    Applikation
    • 96
    • 54
    • 51
    • 18
    • 16
    • 14
    • 14
    • 13
    • 13
    • 11
    • 8
    • 8
    • 8
    • 7
    • 5
    • 4
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Meerschweinchen, Human, Maus, Schwein
    Homologie
    Rat,Dog,Cow,Sheep,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CCL5
    Isotyp
    IgG
    Top Product
    Discover our top product CCL5 Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Irie, Tomofuji, Ekuni, Fukuhara, Uchida, Kataoka, Kobayashi, Kikuchi, Mitani, Shimazaki, Morita: "Age-related changes of CD4+T cell migration and cytokine expression in germ-free and SPF mice periodontium." in: Archives of oral biology, Vol. 87, pp. 72-78, (2018) (PubMed).

    Sun, Roberts, Mauerhan, Hanley: "Biological effects and osteoarthritic disease-modifying activity of small molecule CM-01." in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, (2017) (PubMed).

    Sun, Haines, Roberts, Ruffolo, Mauerhan, Mihalko, Ingram, Cox, Hanley: "Disease-modifying effects of phosphocitrate and phosphocitrate-β-ethyl ester on partial meniscectomy-induced osteoarthritis." in: BMC musculoskeletal disorders, Vol. 16, pp. 270, (2016) (PubMed).

    Hwaiz, Rahman, Syk, Zhang, Thorlacius: "Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury." in: Journal of leukocyte biology, (2015) (PubMed).

    Herder, Iskandar, Kegler, Hansmann, Elmarabet, Khan, Kalkuhl, Deschl, Baumgärtner, Ulrich, Beineke: "Dynamic Changes of Microglia/Macrophage M1 and M2 Polarization in Theiler's Murine Encephalomyelitis." in: Brain pathology (Zurich, Switzerland), Vol. 25, Issue 6, pp. 712-23, (2015) (PubMed).

    Pattappa, Peroglio, Sakai, Mochida, Benneker, Alini, Grad: "CCL5/RANTES is a key chemoattractant released by degenerative intervertebral discs in organ culture." in: European cells & materials, Vol. 27, pp. 124-36; discussion 136, (2014) (PubMed).

  • Target
    CCL5 (Chemokine (C-C Motif) Ligand 5 (CCL5))
    Andere Bezeichnung
    CCL5/RANTES (CCL5 Produkte)
    Synonyme
    Rantes antikoerper, Scya5 antikoerper, D17S136E antikoerper, RANTES antikoerper, SCYA5 antikoerper, SIS-delta antikoerper, SISd antikoerper, TCP228 antikoerper, eoCP antikoerper, MuRantes antikoerper, C-C motif chemokine 5-like antikoerper, C-C motif chemokine ligand 5 antikoerper, chemokine (C-C motif) ligand 5 antikoerper, LOC100230935 antikoerper, CCL5 antikoerper, Ccl5 antikoerper
    Hintergrund

    Synonyms: SISd, eoCP, SCYA5, RANTES, TCP228, D17S136E, SIS-delta, C-C motif chemokine 5, Eosinophil chemotactic cytokine, Small-inducible cytokine A5, T cell-specific protein P228, T-cell-specific protein RANTES, CCL5

    Background: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:1679162, PubMed:13864, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

    Gen-ID
    6352
    UniProt
    P13501
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration
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