PTGS2 Antikörper (AA 501-604)

Produktnummer ABIN672471

Produktdetails anti-PTGS2 Antikörper

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Bindungsspezifität: AA 501-604

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTGS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Cyclooxygenase 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-PTGS2 Antikörper (ABIN672471)

Kellermann, Janssen, Münch, Koch, Schneider-Stock, Cesnjevar, Rüffer: "Deep hypothermic circulatory arrest or tepid regional cerebral perfusion: impact on haemodynamics and myocardial integrity in a randomized experimental trial." in: Interactive cardiovascular and thoracic surgery, Vol. 26, Issue 4, pp. 667-672, (2018) (PubMed).

Chen, Hou, Fan, Jin, Wang: "Sonic hedgehog protein regulates fibroblast growth factor 8 expression in metanephric explant culture from BALB/c mice: Possible mechanisms associated with renal morphogenesis." in: Molecular medicine reports, Vol. 14, Issue 4, pp. 2929-36, (2017) (PubMed).

Hu, Xi, Cao, Yang, Liu, Sheng, Han, Yuan, Guo, Weng, Xu: "The expression of prostaglandin-E2 and its receptor in the oviduct of Chinese brown frog (Rana dybowskii)." in: Prostaglandins & other lipid mediators, Vol. 124, pp. 9-15, (2016) (PubMed).

Li, Xu, Jiang, Bi, Xu, Han: "Lipopolysaccharide induces inflammation and facilitates lung metastasis in a breast cancer model via the prostaglandin E2-EP2 pathway." in: Molecular medicine reports, Vol. 11, Issue 6, pp. 4454-62, (2015) (PubMed).

Liu, Duan, Chang, Zhang, Chu, Li, Dai, Mo, Chang: "Sinomenine sensitizes multidrug-resistant colon cancer cells (Caco-2) to doxorubicin by downregulation of MDR-1 expression." in: PLoS ONE, Vol. 9, Issue 6, pp. e98560, (2015) (PubMed).

Wallace, Zheng, Kanazawa, Shih: "Immunopathology of inflammatory bowel disease." in: World journal of gastroenterology : WJG, Vol. 20, Issue 1, pp. 6-21, (2014) (PubMed).

Li, Li, Mu, Zhang, Yao, Li, Niu: "Protective effect of sanguinarine on LPS-induced endotoxic shock in mice and its effect on LPS-induced COX-2 expression and COX-2 associated PGE2 release from peritoneal macrophages." in: International immunopharmacology, Vol. 22, Issue 2, pp. 311-7, (2014) (PubMed).

Zhang, Wu, Wan, Song, Xu, Xu, Chang, Tai, Dong, Liu: "Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats." in: World journal of gastroenterology : WJG, Vol. 20, Issue 6, pp. 1614-22, (2014) (PubMed).

de Moraes, Maia, de Lima, Dias, Raposo-Ferreira, Sudano, Junior, Oba et al.: "Temporal analysis of prostaglandin F2? receptor, caspase 3, and cyclooxygenase 2 messenger RNA expression and prostaglandin F2? receptor and cyclooxygenase 2 protein expression in endometrial tissue ..." in: Theriogenology, Vol. 83, Issue 2, pp. 276-84, (2014) (PubMed).

Gao, Wen, Yang, Lu, Tong, Huang, Liu, Tang: "Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis." in: PLoS ONE, Vol. 8, Issue 7, pp. e69309, (2013) (PubMed).

Chu, He, Kuang, Ren, Gou: "Celastrol protects kidney against ischemia-reperfusion-induced injury in rats." in: The Journal of surgical research, Vol. 186, Issue 1, pp. 398-407, (2013) (PubMed).

Li, Wang, Jiang, Xu, Zhang, Liu, Zhai: "Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo." in: International journal of molecular sciences, Vol. 12, Issue 1, pp. 668-81, (2011) (PubMed).

Li, Jiang, Xu, Wang, Zhang, Liu, Zhai: "Cyclin D1 expression and the inhibitory effect of celecoxib on ovarian tumor growth in vivo." in: International journal of molecular sciences, Vol. 11, Issue 10, pp. 3999-4013, (2010) (PubMed).

Details zu PTGS2

Target: PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) (PTGS2))

Andere Bezeichnung: Cyclooxygenase 2 (PTGS2 Produkte)

Synonyme: COX-2 antikoerper, COX2 antikoerper, GRIPGHS antikoerper, PGG/HS antikoerper, PGHS-2 antikoerper, PHS-2 antikoerper, hCox-2 antikoerper, Cox-2 antikoerper, Pghs2 antikoerper, TIS10 antikoerper, Cox2 antikoerper, cox-2 antikoerper, CEF147 antikoerper, PGHS2 antikoerper, PHSII antikoerper, cox2 antikoerper, gripghs antikoerper, pgg/hs antikoerper, pghs-2 antikoerper, phs-2 antikoerper, PTGS2 antikoerper, hcox-2 antikoerper, fj02a10 antikoerper, ptgs2 antikoerper, unp1239 antikoerper, wu:fj02a10 antikoerper, zCOX-2 antikoerper, si:dkey-97o5.6 antikoerper, prostaglandin-endoperoxide synthase 2 antikoerper, prostaglandin G/H synthase 2 antikoerper, prostaglandin-endoperoxide synthase 2S homeolog antikoerper, prostaglandin-endoperoxide synthase 2a antikoerper, prostaglandin-endoperoxide synthase 2b antikoerper, PTGS2 antikoerper, Ptgs2 antikoerper, LOC100136456 antikoerper, ptgs2.S antikoerper, ptgs2 antikoerper, ptgs2a antikoerper, ptgs2b antikoerper

Hintergrund:

Synonyms: COX2, Cox-2, PHS-2, Pghs2, TIS1, PGHS-2, Prostaglandin G/H synthase 2, Cyclooxygenase-2, Glucocorticoid-regulated inflammatory cyclooxygenase, Gripghs, Macrophage activation-associated marker protein P71/73, PES-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, Prostaglandin-endoperoxide synthase 2, TIS1 protein, Ptgs2, Pghs-b

Background: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Gen-ID: 19225

UniProt: Q05769

Pathways: Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation