CD68 Antikörper (AA 21-120)

Produktnummer ABIN671406

Produktdetails anti-CD68 Antikörper

Target: CD68 (CD68 Molecule (CD68))

Bindungsspezifität: AA 21-120

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD68 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunocytochemistry (ICC)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse CD68

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CD68 Antikörper (ABIN671406)

Guo, Jin, Jin, Chen, Lei, Wang: "Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and inflammatory response." in: Acta biomaterialia, Vol. 82, pp. 44-55, (2019) (PubMed).

Zhao, Yin, Fang, Xu, Sun, Xu, Liu, Peng: "Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway." in: International immunopharmacology, Vol. 65, pp. 458-469, (2019) (PubMed).

Nishizawa, Iguchi, Fukuoka, Takahashi, Suda, Bando, Matsumoto, Yoshida, Odake, Ogawa, Takahashi: "IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner." in: Scientific reports, Vol. 6, pp. 34605, (2018) (PubMed).

Ganguly, Sahu, Ohanyan, Haney, Chavez, Shah, Yalamanchili, Raman: "Oral chromium picolinate impedes hyperglycemia-induced atherosclerosis and inhibits proatherogenic protein TSP-1 expression in STZ-induced type 1 diabetic ApoE(-/-) mice." in: Scientific reports, Vol. 7, pp. 45279, (2017) (PubMed).

Kugo, Zaima, Onozato, Miyamoto, Hashimoto, Yanagimoto, Moriyama: "Suppressive effects of dietary EPA-rich fish oil on the degradation of elastin fibers in the aortic wall in nicotine-administered mice." in: Food & function, Vol. 8, Issue 8, pp. 2829-2835, (2017) (PubMed).

Vendrov, Stevenson, Alahari, Pan, Wickline, Madamanchi, Runge: "Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice." in: Journal of the American Heart Association, Vol. 6, Issue 11, (2017) (PubMed).

Müller, Vogl, Pappritz, Miteva, Savvatis, Rohde, Most, Lassner, Pieske, Kühl, Van Linthout, Tschöpe: "Pathogenic Role of the Damage-Associated Molecular Patterns S100A8 and S100A9 in Coxsackievirus B3-Induced Myocarditis." in: Circulation. Heart failure, Vol. 10, Issue 11, (2017) (PubMed).

Xu, Yuan, Li, Dewey, Li, Zhang: "Lysosomal cholesterol accumulation in macrophages leading to coronary atherosclerosis in CD38(-/-) mice." in: Journal of cellular and molecular medicine, Vol. 20, Issue 6, pp. 1001-13, (2016) (PubMed).

Kang, Kim, Joung, Lee, You, Choi, Ryu, Ko, Lee, Lee, Ku, Shong, Lee, Kim: "The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154003, (2016) (PubMed).

Xu, Zhang, Halquist, Yuan, Henderson, Dewey, Li, Li, Zhang: "Simvastatin promotes NPC1-mediated free cholesterol efflux from lysosomes through CYP7A1/LXRα signalling pathway in oxLDL-loaded macrophages." in: Journal of cellular and molecular medicine, (2016) (PubMed).

Bang, Seo, Seo, Jo, Jung, Yu, Park, Park: "Bacillus subtilis KCTC 11782BP-Produced Alginate Oligosaccharide Effectively Suppresses Asthma via T-Helper Cell Type 2-Related Cytokines." in: PLoS ONE, Vol. 10, Issue 2, pp. e0117524, (2015) (PubMed).

Shang, Bai, Wang, Song, Guo, Zhang, Wang: "Delivery of Adipose-Derived Stem Cells Attenuates Adipose Tissue Inflammation and Insulin Resistance in Obese Mice Through Remodeling Macrophage Phenotypes." in: Stem cells and development, Vol. 24, Issue 17, pp. 2052-64, (2015) (PubMed).

Hong, Lee, Ko, Park, Park, Choi, Yoon, Ahn, Park, Woo, Oh: "Neonatal systemic inflammation in rats alters retinal vessel development and simulates pathologic features of retinopathy of prematurity." in: Journal of neuroinflammation, Vol. 11, pp. 87, (2014) (PubMed).

Wang, Hu, Wang, Gu, Gao, Cao, Zheng: "5-Aminolevulinic acid-mediated sonodynamic therapy reverses macrophage and dendritic cell passivity in murine melanoma xenografts." in: Ultrasound in medicine & biology, Vol. 40, Issue 9, pp. 2125-33, (2014) (PubMed).

Savvatis, Müller, Fröhlich, Pappritz, Zietsch, Hamdani, Grote, Schieffer, Klingel, Van Linthout, Linke, Schultheiss, Tschöpe: "Interleukin-6 receptor inhibition modulates the immune reaction and restores titin phosphorylation in experimental myocarditis." in: Basic research in cardiology, Vol. 109, Issue 6, pp. 449, (2014) (PubMed).

Xiao, Zou, Yang, Rehman, Ansari, Yuan, Zhou, Cui, Peng, Song: "The role of visfatin on the regulation of inflammation and apoptosis in the spleen of LPS-treated rats." in: Cell and tissue research, (2014) (PubMed).

Wang, Dong, Liu, Song, Song, Shang, Jiang, Guo, Zhang: "Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance." in: Diabetes, Vol. 62, Issue 12, pp. 4132-43, (2014) (PubMed).

Zeng, Zhang, Li, Yang, Chen, Liu: "A new method to isolate and culture rat kupffer cells." in: PLoS ONE, Vol. 8, Issue 8, pp. e70832, (2013) (PubMed).

Chen, Bai, Liao, Peng, Wu, Wang, Zeng, Xie: "Electrospun poly(L-lactide)/poly(?-caprolactone) blend nanofibrous scaffold: characterization and biocompatibility with human adipose-derived stem cells." in: PLoS ONE, Vol. 8, Issue 8, pp. e71265, (2013) (PubMed).

Wu, Wu, Wu, Zhao, Li, Varghese, Moorhead, Powis, Chen, Ruan: "Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet." in: The Journal of endocrinology, Vol. 219, Issue 3, pp. 195-204, (2013) (PubMed).

Details zu CD68

Target: CD68 (CD68 Molecule (CD68))

Andere Bezeichnung: CD68 (CD68 Produkte)

Hintergrund:

Synonyms: Lamp4, gp11, Scard1, Macrosialin, CD68

Background: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Gen-ID: 12514

UniProt: P31996