Ghrelin Antikörper (AA 31-117)

Produktnummer ABIN668991

Produktdetails anti-Ghrelin Antikörper

Target: Ghrelin (GHRL)

Bindungsspezifität: AA 31-117

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ghrelin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ghrelin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Ghrelin Antikörper (ABIN668991)

Liu, Liu, Li, Chen, Gu et al.: "Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and ..." in: International journal of molecular medicine, Vol. 42, Issue 6, pp. 3037-3046, (2019) (PubMed).

Wölnerhanssen, Moran, Burdyga, Meyer-Gerspach, Peterli, Manz, Thumshirn, Daly, Beglinger, Shirazi-Beechey: "Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals." in: Scientific reports, Vol. 7, Issue 1, pp. 8174, (2017) (PubMed).

Dai, Jiang, Yuan, Yang, Yang, Huang: "Effects of zearalenone-diet on expression of ghrelin and PCNA genes in ovaries of post-weaning piglets." in: Animal reproduction science, Vol. 168, pp. 126-37, (2016) (PubMed).

Lemarié, Beauchamp, Dayot, Duby, Legrand, Rioux: "Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat." in: PLoS ONE, Vol. 10, Issue 7, pp. e0133600, (2015) (PubMed).

Wang, Song, Li, Liu, Ma, Mao, Wu, Wu, Li, Guan, Liu: "Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin." in: Neural regeneration research, Vol. 9, Issue 2, pp. 205-12, (2014) (PubMed).

Details zu Ghrelin

Target: Ghrelin (GHRL)

Andere Bezeichnung: Ghrelin (GHRL Produkte)

Synonyme: 2210006E23Rik antikoerper, Ghr antikoerper, MTLRP antikoerper, MTLRPAP antikoerper, m46 antikoerper, Gh1-1 antikoerper, GRHL antikoerper, MTLRP-AP antikoerper, GHR antikoerper, ghrelin antikoerper, ghrelin and obestatin prepropeptide antikoerper, ghrelin/obestatin prepropeptide antikoerper, Ghrl antikoerper, GHRL antikoerper, ghrl antikoerper

Hintergrund:

Synonyms: MTLRP, Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46, GHRL, UNQ524/PRO1066

Background: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation. Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).

Gen-ID: 51738

UniProt: Q9UBU3

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Negative Regulation of Hormone Secretion, Synaptic Membrane, Feeding Behaviour