WIPI2 Antikörper (N-Term)

Produktnummer ABIN657237

Produktdetails anti-WIPI2 Antikörper

Target: WIPI2 (WD Repeat Domain, Phosphoinositide Interacting 2 (WIPI2))

Bindungsspezifität: AA 4-32, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WIPI2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This WIPI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human WIPI2.

Klon: RB33312

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-WIPI2 Antikörper (ABIN657237)

Burbulla, Fitzgerald, Stegen, Westermeier, Thost, Kato, Mokranjac, Sauerwald, Martins, Woitalla, Rapaport, Riess, Proikas-Cezanne, Rasse, Krüger: "Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1." in: Cell death & disease, Vol. 5, pp. e1180, (2014) (PubMed).

Nemazanyy, Blaauw, Paolini, Caillaud, Protasi, Mueller, Proikas-Cezanne, Russell, Guan, Nishino, Sandri, Pende, Panasyuk: "Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease." in: EMBO molecular medicine, Vol. 5, Issue 6, pp. 870-90, (2013) (PubMed).

Details zu WIPI2

Target: WIPI2 (WD Repeat Domain, Phosphoinositide Interacting 2 (WIPI2))

Andere Bezeichnung: WIPI2 (WIPI2 Produkte)

Synonyme: ATG18B antikoerper, Atg21 antikoerper, WIPI-2 antikoerper, 1110018O08Rik antikoerper, 2510001I10Rik antikoerper, WD repeat domain, phosphoinositide interacting 2 L homeolog antikoerper, WD repeat domain, phosphoinositide interacting 2 antikoerper, wipi2.L antikoerper, WIPI2 antikoerper, Wipi2 antikoerper

Hintergrund: WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).

Molekulargewicht: 49408

NCBI Accession: NP_001028690, NP_001028691, NP_001028692, NP_001265228, NP_056425, NP_057087

UniProt: Q9Y4P8