NLRC4 Antikörper (N-Term)

Produktnummer ABIN657230

Produktdetails anti-NLRC4 Antikörper

Target: NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))

Bindungsspezifität: AA 116-145, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NLRC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the N-terminal region of human NLRC4.

Klon: RB33296

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu NLRC4

Target: NLRC4 (NLR Family, CARD Domain Containing 4 (NLRC4))

Andere Bezeichnung: NLRC4 (NLRC4 Produkte)

Synonyme: CARD12 antikoerper, CLAN antikoerper, CLAN1 antikoerper, CLANA antikoerper, CLANB antikoerper, CLANC antikoerper, CLAND antikoerper, CLR2.1 antikoerper, IPAF antikoerper, 9530011P19Rik antikoerper, Card12 antikoerper, NLR family CARD domain containing 4 antikoerper, NLR family, CARD domain containing 4 antikoerper, NLRC4 antikoerper, Nlrc4 antikoerper

Hintergrund: In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.

Molekulargewicht: 116159

NCBI Accession: NP_001186067, NP_001186068, NP_067032

UniProt: Q9NPP4

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome