p38 Antikörper (MAP kinase p38) (AA 158-192)

Details for Product anti-p38 Antibody No. ABIN656420, Anbieter: Anmelden zum Anzeigen
Antigen
  • CSBP
  • CSBP1
  • CSBP2
  • CSPB1
  • EXIP
  • Mxi2
  • PRKM14
  • PRKM15
  • RK
  • SAPK2A
  • p38
  • p38ALPHA
  • mitogen-activated protein kinase 14
  • MAPK14
Epitop
AA 158-192, Center, Thr180, Tyr182
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Reaktivität
Human
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38
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Wirt
Kaninchen
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85
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser p38 Antikörper ist unkonjugiert
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Applikation
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This MAPK14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-192 AA from the Central region of human MAPK14.
Klon RB30167
Isotyp Ig
Spezifität This p38 MAPK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-192 amino acids from the Central region of human p38 MAPK.
Homologie Mouse (Murine),Rat (Rattus),Zebrafish
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung p38 MAPK (p38 Antibody Abstract)
Hintergrund The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms: Mitogen-activated protein kinase 14,MAPK14,CSBP, CSBP1, CSBP2, CSPB1, MXI2
Molekulargewicht 41293 DA
Gen-ID 1432
NCBI Accession NP_620581, NP_001306, NP_620582, NP_620583
UniProt Q16539
Forschungsgebiet Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Signaling, Cell Structure
Pathways MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Hepatitis C, Toll-Like Receptors Cascades, Autophagie, Thromboxane A2 Receptor Signaling
Applikationshinweise IF = 1:10-50, WB = 1:1000, IHC (p) = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.38 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung p38 MAPK Antibody (Center T180/Y182) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.Precaut.
Haltbarkeit 6 months
Bilder des Herstellers
Immunofluorescence (IF) image for anti-MAP kinase p38 (p38) (AA 158-192), (Center), (Thr180), (Tyr182) antibody (ABIN656420) Fluorescent confocal image of A549 cell stained with MAPK14 Antibody (Center T180/Y18...
Western Blotting (WB) image for anti-MAP kinase p38 (p38) (AA 158-192), (Center), (Thr180), (Tyr182) antibody (ABIN656420) MAPK14 Antibody (Center T180/Y182) western blot analysis in Jurkat cell line lysates...
Immunohistochemistry (IHC) image for anti-MAP kinase p38 (p38) (AA 158-192), (Center), (Thr180), (Tyr182) antibody (ABIN656420) MAPK14 Antibody (Center T180/Y182) immunohistochemistry analysis in formalin fixed an...
Allgemeine Veröffentlichungen Pan, Li, Huang, Papadimos, Pan, Chen: "Synergistic activation of NF-{kappa}B by bacterial chemoattractant and TNF{alpha} is mediated by p38 MAPK-dependent RelA acetylation." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34348-54, 2010 (PubMed).

Marchant, Singhera, Utokaparch, Hackett, Boyd, Luo, Si, Dorscheid, McManus, Hegele: "Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism." in: Journal of virology, Vol. 84, Issue 21, pp. 11359-73, 2010 (PubMed).

Arana-Argáez, Delgado-Rizo, Pizano-Martínez, Martínez-Garcia, Martín-Márquez, Muñoz-Gómez, Petri, Armendáriz-Borunda, Espinosa-Ramírez, Zúñiga-Tamayo, Herrera-Esparza, Vázquez-Del Mercado: "Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 32824-33, 2010 (PubMed).

Ferreiro, Barragan, Gubern, Ballestar, Joaquin, Posas: "The p38 SAPK is recruited to chromatin via its interaction with transcription factors." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31819-28, 2010 (PubMed).

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