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SMPD1 Antikörper (C-Term)

SMPD1 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB31029 unconjugated
Produktnummer ABIN656161
  • Target Alle SMPD1 Antikörper anzeigen
    SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 391-419, C-Term
    Reaktivität
    • 45
    • 21
    • 20
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 38
    • 6
    • 1
    Kaninchen
    Klonalität
    • 39
    • 6
    Polyklonal
    Konjugat
    • 21
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SMPD1 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 21
    • 19
    • 13
    • 13
    • 12
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SMPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the C-terminal region of human SMPD1.
    Klon
    RB31029
    Isotyp
    IgG
  • Applikationshinweise
    WB: 1:2000. WB: 1:4000. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500. FC: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    SMPD1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    Haltbarkeit
    6 months
  • Ullio, Casas, Brunk, Sala, Fabriàs, Ghidoni, Bonelli, Baccino, Autelli: "Sphingosine mediates TNF?-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells." in: Journal of lipid research, Vol. 53, Issue 6, pp. 1134-43, (2012) (PubMed).

  • Target
    SMPD1 (Sphingomyelin phosphodiesterase 1, Acid Lysosomal (SMPD1))
    Andere Bezeichnung
    SMPD1 (SMPD1 Produkte)
    Synonyme
    ASM antikoerper, ASMASE antikoerper, NPD antikoerper, A-SMase antikoerper, Zn-SMase antikoerper, aSMase antikoerper, SMPD1 antikoerper, sphingomyelin phosphodiesterase 1 antikoerper, sphingomyelin phosphodiesterase 1, acid lysosomal antikoerper, sphingomyelin phosphodiesterase antikoerper, SMPD1 antikoerper, Smpd1 antikoerper, LOC5578088 antikoerper
    Hintergrund
    The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq].
    Molekulargewicht
    69936
    Gen-ID
    6609
    NCBI Accession
    NP_000534, NP_001007594
    UniProt
    P17405
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