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RECQL2 Antikörper (AA 787-816)

WRN Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB17383 unconjugated
Produktnummer ABIN656017
  • Target Alle RECQL2 (WRN) Antikörper anzeigen
    RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))
    Bindungsspezifität
    • 7
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 787-816
    Reaktivität
    • 41
    • 2
    • 1
    Human
    Wirt
    • 34
    • 7
    Kaninchen
    Klonalität
    • 34
    • 7
    Polyklonal
    Konjugat
    • 24
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RECQL2 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 21
    • 12
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 787-816 amino acids from the Central region of human WRN.
    Klon
    RB17383
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:100. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Kawakubo-Yasukochi, Morioka, Hazekawa, Yasukochi, Nishinakagawa, Ono, Kawano, Nakamura, Nakashima: "miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment." in: Molecular carcinogenesis, Vol. 57, Issue 2, pp. 295-302, (2018) (PubMed).

  • Target
    RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))
    Andere Bezeichnung
    WRN (WRN Produkte)
    Synonyme
    RECQ3 antikoerper, RECQL2 antikoerper, RECQL3 antikoerper, xBLM antikoerper, recq2 antikoerper, recql2 antikoerper, recql3 antikoerper, AI846146 antikoerper, ffa-1 antikoerper, xwrn antikoerper, RGD1564788 antikoerper, Werner syndrome RecQ like helicase antikoerper, mediator of RNA polymerase II transcription subunit 34 antikoerper, Bloom syndrome RecQ like helicase antikoerper, Werner syndrome, RecQ helicase-like L homeolog antikoerper, WRN antikoerper, LOC9327212 antikoerper, blm antikoerper, Wrn antikoerper, wrn.L antikoerper
    Hintergrund
    This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
    Molekulargewicht
    162461
    Gen-ID
    7486
    NCBI Accession
    NP_000544
    UniProt
    Q14191
    Pathways
    DNA Reparatur
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