Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This AKR1C3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the Central region of human AKR1C3.
AKR1C3 antikoerper, PGFS antikoerper, MGC134333 antikoerper, DD3 antikoerper, DDX antikoerper, HA1753 antikoerper, HAKRB antikoerper, HAKRe antikoerper, HSD17B5 antikoerper, hluPGFS antikoerper, Akr1c18 antikoerper, aldo-keto reductase family 1, member C3 L homeolog antikoerper, aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) antikoerper, aldo-keto reductase family 1 member C2 antikoerper, aldo-keto reductase family 1 member C3 antikoerper, aldo-keto reductase family 1, member C3 antikoerper, akr1c3.L antikoerper, AKR1C3 antikoerper, LOC722496 antikoerper, Akr1c3 antikoerper
Hintergrund
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.