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KLLN Antikörper (C-Term)

KLLN Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB29503 unconjugated
Produktnummer ABIN655558
  • Target Alle KLLN Antikörper anzeigen
    KLLN (Killin, p53-Regulated DNA Replication Inhibitor (KLLN))
    Bindungsspezifität
    • 7
    • 7
    • 7
    • 1
    • 1
    • 1
    AA 136-163, C-Term
    Reaktivität
    Human
    Wirt
    • 25
    Kaninchen
    Klonalität
    • 25
    Polyklonal
    Konjugat
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser KLLN Antikörper ist unkonjugiert
    Applikation
    • 17
    • 14
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This KILLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-163 amino acids from the C-terminal region of human KILLIN.
    Klon
    RB29503
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Wang, Roma, Nolley, Abdul-Karim, Peehl, Eng: "Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma." in: Endocrine-related cancer, Vol. 21, Issue 4, pp. 579-86, (2014) (PubMed).

    Wang, Yu, He, Romigh, Altemus, Eng: "Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation." in: Molecular cancer therapeutics, Vol. 13, Issue 2, pp. 517-27, (2014) (PubMed).

    Wang, He, Yu, Eng: "Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas." in: Human molecular genetics, Vol. 22, Issue 11, pp. 2263-72, (2013) (PubMed).

  • Target
    KLLN (Killin, p53-Regulated DNA Replication Inhibitor (KLLN))
    Andere Bezeichnung
    KILLIN (KLLN Produkte)
    Synonyme
    CWS4 antikoerper, KILLIN antikoerper, killin, p53-regulated DNA replication inhibitor antikoerper, KLLN antikoerper
    Hintergrund
    DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating TP53/p53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double-and single-stranded DNA.
    Molekulargewicht
    19958
    Gen-ID
    100144748
    NCBI Accession
    NP_001119521
    UniProt
    B2CW77
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