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OPN-A,b (AA 14-40), (N-Term) Antikörper

Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB19160 unconjugated
Produktnummer ABIN655514
  • Target
    OPN-A,b
    Bindungsspezifität
    AA 14-40, N-Term
    Reaktivität
    Human
    Wirt
    • 6
    Kaninchen
    Klonalität
    • 6
    Polyklonal
    Konjugat
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 6
    • 6
    • 6
    • 5
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This OPN-a/b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-40 amino acids from the N-terminal region of human OPN-a/b.
    Klon
    RB19160
    Isotyp
    Ig Fraction
  • Applikationshinweise
    IF: 1:25. WB: 1:1000. WB: 1:2000. WB: 1:2000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Tu, Li, Zeng, Deng, Gao, Xiao, Luo, Jiang, Li, Lei: "MicroRNA-127-5p regulates osteopontin expression and osteopontin-mediated proliferation of human chondrocytes." in: Scientific reports, Vol. 6, pp. 25032, (2018) (PubMed).

    Wang, Wang, Zhang, Deng, Long: "NEAT1/miR-181c Regulates Osteopontin (OPN)-Mediated Synoviocyte Proliferation in Osteoarthritis." in: Journal of cellular biochemistry, Vol. 118, Issue 11, pp. 3775-3784, (2018) (PubMed).

    Liang, Xu, Zhou, Liu, Ge, Chen, Tu: "MALAT1/miR-127-5p Regulates Osteopontin (OPN)-Mediated Proliferation of Human Chondrocytes Through PI3K/Akt Pathway." in: Journal of cellular biochemistry, Vol. 119, Issue 1, pp. 431-439, (2018) (PubMed).

    Li, Jiang, Wang, Deng, Zeng, Tu, Li, Xiao, Gao, Luo, Lei: "Osteopontin Promotes Expression of Matrix Metalloproteinase 13 through NF-κB Signaling in Osteoarthritis." in: BioMed research international, Vol. 2016, pp. 6345656, (2016) (PubMed).

  • Target
    OPN-A,b
    Hintergrund
    Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).
    Molekulargewicht
    35423
    Gen-ID
    6696
    NCBI Accession
    NP_000573, NP_001035147, NP_001035149, NP_001238758, NP_001238759
    UniProt
    P10451
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