Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CYP2B6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6.
CYP2B6
Reaktivität: Human
WB, ELISA
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
IF: 1:25. WB: 1:2000. IHC-P: 1:10~50
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Okamatsu, Komatsu, Ono, Inoue, Uchide, Onaga, Endoh, Kitazawa, Hiraga, Uno, Teraoka: "Characterization of feline cytochrome P450 2B6." in: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 2, pp. 93-102, (2017) (PubMed).
Hlavá?, Brynychová, Václavíková, Ehrlichová, Vrána, Pecha, Trnková, Kodet, Mrhalová, Kubá?ková, Gat?k, Vážan, Sou?ek: "The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients." in: Medicine, Vol. 93, Issue 28, pp. e255, (2014) (PubMed).
Target
CYP2B6
(Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 (CYP2B6))
CPB6 antikoerper, CYP2B antikoerper, CYP2B7 antikoerper, CYP2B7P antikoerper, CYPIIB6 antikoerper, EFVM antikoerper, IIB1 antikoerper, P450 antikoerper, CPF3 antikoerper, CYP4F antikoerper, LTB4H antikoerper, CYP2B30 antikoerper, CYP2B11 antikoerper, CYPIIB11 antikoerper, 21-OH antikoerper, 21OH antikoerper, 21OHA antikoerper, 21OHB antikoerper, CYP21OH-A antikoerper, Cyp21 antikoerper, Cyp21-ps1 antikoerper, Cyp21B antikoerper, Cyp21a2-ps antikoerper, Cyp21a2ps antikoerper, Oh21-1 antikoerper, Oh21-2 antikoerper, CYP2B6 antikoerper, cytochrome P450 family 2 subfamily B member 6 antikoerper, cytochrome P450 family 4 subfamily F member 3 antikoerper, cytochrome P450, family 2, subfamily B, polypeptide 6 antikoerper, cytochrome P450 family 2 subfamily B member 6 L homeolog antikoerper, cytochrome P450 2B11 antikoerper, cytochrome P450, family 21, subfamily a, polypeptide 1 antikoerper, cytochrome P450 subfamily 2B antikoerper, cytochrome P450 2B11-like antikoerper, CYP2B6 antikoerper, CYP4F3 antikoerper, cyp2b6.L antikoerper, Cyp21a1 antikoerper, LOC100068603 antikoerper
Hintergrund
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described, however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.