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BARD1 Antikörper (N-Term)

BARD1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB19063 unconjugated
Produktnummer ABIN654621
  • Target Alle BARD1 Antikörper anzeigen
    BARD1 (BRCA1 Associated RING Domain 1 (BARD1))
    Bindungsspezifität
    • 16
    • 8
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 101-131, N-Term
    Reaktivität
    • 45
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 44
    • 2
    Kaninchen
    Klonalität
    • 44
    • 2
    Polyklonal
    Konjugat
    • 18
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BARD1 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 21
    • 14
    • 13
    • 13
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This BARD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human BARD1.
    Klon
    RB19063
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product BARD1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    BARD1 (BRCA1 Associated RING Domain 1 (BARD1))
    Andere Bezeichnung
    BARD1 (BARD1 Produkte)
    Synonyme
    BARD1 antikoerper, LOC100147913 antikoerper, ENSMUSG00000060893 antikoerper, ENSMUSG00000073653 antikoerper, BRCA1 associated RING domain 1 antikoerper, BARD1 antikoerper, bard1 antikoerper, Bard1 antikoerper
    Hintergrund
    BARD1 is a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.
    Molekulargewicht
    86648
    Gen-ID
    580
    NCBI Accession
    NP_000456
    UniProt
    Q99728
    Pathways
    DNA Reparatur
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