This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This AKR1C3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-36 amino acids from the N-terminal region of human AKR1C3.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit
6 months
Guo, Wang, Liu, Myatt, Sun: "Induction of PGF2? synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts." in: Endocrinology, Vol. 155, Issue 8, pp. 3017-24, (2014) (PubMed).
Target
AKR1C3
(Aldo-Keto Reductase Family 1, Member C3 (3-alpha Hydroxysteroid Dehydrogenase, Type II) (AKR1C3))
AKR1C3 antikoerper, PGFS antikoerper, MGC134333 antikoerper, DD3 antikoerper, DDX antikoerper, HA1753 antikoerper, HAKRB antikoerper, HAKRe antikoerper, HSD17B5 antikoerper, hluPGFS antikoerper, Akr1c18 antikoerper, aldo-keto reductase family 1, member C3 L homeolog antikoerper, aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) antikoerper, aldo-keto reductase family 1 member C2 antikoerper, aldo-keto reductase family 1 member C3 antikoerper, aldo-keto reductase family 1, member C3 antikoerper, akr1c3.L antikoerper, AKR1C3 antikoerper, LOC722496 antikoerper, Akr1c3 antikoerper
Hintergrund
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.