CPSF4 Antikörper (AA 96-123)

Produktnummer ABIN653570

Produktdetails anti-CPSF4 Antikörper

Target: CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))

Bindungsspezifität: AA 96-123

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CPSF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, Rat, X

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CPSF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human CPSF4.

Klon: RB23266

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu CPSF4

Target: CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))

Andere Bezeichnung: CPSF4 (CPSF4 Produkte)

Synonyme: cpsf30 antikoerper, nar antikoerper, neb1 antikoerper, 30kDa antikoerper, C79664 antikoerper, CPSF30 antikoerper, NAR antikoerper, NEB1 antikoerper, cleavage and polyadenylation specific factor 4 antikoerper, cleavage and polyadenylation specific factor 4, 30kDa antikoerper, cleavage and polyadenylation specific factor 4 S homeolog antikoerper, CPSF4 antikoerper, Cpsf4 antikoerper, LOC733099 antikoerper, LOC100360200 antikoerper, cpsf4.S antikoerper, cpsf4 antikoerper

Hintergrund: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.

Molekulargewicht: 30255

Gen-ID: 10898

NCBI Accession: NP_001075028, NP_006684

UniProt: O95639