APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 735-763)

Details for Product anti-APP Antibody No. ABIN652995, Anbieter: Anmelden zum Anzeigen
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein
  • amyloid beta (A4) precursor protein a
  • beta amyloid protein precursor
  • Appl
  • APP
  • app
  • App
  • appa
  • LOC100009546
Epitop
AA 735-763, Tyr756
107
107
72
39
37
32
31
19
17
15
15
14
14
13
12
10
8
7
7
7
7
7
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
944
388
369
40
27
21
19
18
15
13
12
10
7
7
4
4
4
3
2
2
1
Wirt
Kaninchen
657
263
52
7
2
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser APP Antikörper ist unkonjugiert
51
43
41
17
15
14
14
14
13
13
13
13
13
13
13
8
8
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
672
403
297
165
159
122
90
57
40
35
17
15
15
10
8
3
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-763 AA from human APP.
Klon RB7005
Isotyp Ig
Spezifität This APP-Y756 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Y756 region of human APP .
Homologie Mouse (Murine),Pig (Porcine),Monkey,Rat (Rattus)
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung APP (APP Antibody Abstract)
Hintergrund APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).
Synonyms: C31, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 59, AICD-59, AID(59), Gamma-CTF(59), Gamma-secretase C-terminal fragment 59, C80, P3(40), P3(42), C83, Beta-APP40, Beta-amyloid protein 40, Beta-APP42, Beta-amyloid protein 42, C99, Soluble APP-beta, S-APP-beta, Soluble APP-alpha, S-APP-alpha, N-APP, Protease nexin-II, PN-II, Cerebral vascular amyloid peptide, CVAP, PreA4, APPI, APP, ABPP, Alzheimer disease amyloid protein, Amyloid beta A4 protein, AD1, A4
Molekulargewicht 86943 DA
Gen-ID 351
UniProt P05067
Forschungsgebiet Apoptosis/Necrosis, Signaling, Cell Structure, Transcription Factors, Neurology
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikationshinweise WB = 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.467 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 735-763), (Tyr756) antibody (ABIN652995) Western blot analysis of APP-pY756 (ABIN652995) in T47D cell line lysates (35 µg/lane...
Allgemeine Veröffentlichungen Chen, Fernandez: "Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein." in: Biochemical and biophysical research communications, Vol. 330, Issue 3, pp. 714-21, 2005 (PubMed).

Yamamoto, Horiba, Buescher, Huang, Gendelman, Ransohoff, Ikezu: "Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition." in: The American journal of pathology, Vol. 166, Issue 5, pp. 1475-85, 2005 (PubMed).

Moir, Tseitlin, Soscia, Hyman, Irizarry, Tanzi: "Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients." in: The Journal of biological chemistry, Vol. 280, Issue 17, pp. 17458-63, 2005 (PubMed).

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