Glutaminase Antikörper (C-Term)

Produktnummer ABIN652757

Produktdetails anti-Glutaminase Antikörper

Target: Glutaminase (GLS)

Bindungsspezifität: AA 516-545, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutaminase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GLS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-545 amino acids from the C-terminal region of human GLS.

Klon: RB22875

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IF: 1:25. IF: 1:25. IF: 1:25. WB: 1:1000. WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze-thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Haltbarkeit: 6 months

Referenzen für anti-Glutaminase Antikörper (ABIN652757)

Lukey, Greene, Erickson, Wilson, Cerione: "The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy." in: Nature communications, Vol. 7, pp. 11321, (2016) (PubMed).

Details zu Glutaminase

Target: Glutaminase (GLS)

Andere Bezeichnung: GLS (GLS Produkte)

Synonyme: Glut antikoerper, RATGLUT antikoerper, gls antikoerper, si:dz87i4.2 antikoerper, wu:fa97e05 antikoerper, GA antikoerper, PAG antikoerper, AAD20 antikoerper, GAC antikoerper, GAM antikoerper, GLS1 antikoerper, KGA antikoerper, AI314027 antikoerper, 6330442B14 antikoerper, B230365M23Rik antikoerper, CG8772 antikoerper, CG8872 antikoerper, Dmel\\CG42708 antikoerper, Dmel_CG8772 antikoerper, BA3155 antikoerper, glutaminase antikoerper, glutaminase b antikoerper, Glutaminase antikoerper, glutaminase kidney isoform, mitochondrial antikoerper, Gls antikoerper, GLS antikoerper, gls antikoerper, glsb antikoerper, glsA2 antikoerper, glsA-2 antikoerper, Arnit_3113 antikoerper, Celal_2913 antikoerper, Celly_0289 antikoerper, Weevi_2101 antikoerper, Mesop_4683 antikoerper, LOC100069617 antikoerper

Hintergrund: Sahai (1983) demonstrated phosphate-activated glutaminase (EC 3.5.1.2) in human platelets. It is the major enzyme yielding glutamate from glutamine. Significance of the enzyme derives from its possible implication in behavior disturbances in which glutamate acts as a neurotransmitter(Prusiner, 1981). High heritability of platelet glutaminase was indicated by studies of Sahai and Vogel (1983) [PubMed 6682827] who found an intraclass correlation coefficient of 0.96 for monozygotic twins and 0.53 for dizygotic twins.

Molekulargewicht: 73461

Gen-ID: 2744

NCBI Accession: NP_001243239, NP_055720

UniProt: O94925

Pathways: Feeding Behaviour, Dicarboxylic Acid Transport, Warburg Effekt