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BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 116-143) Antikörper

BABAM1 Reaktivität: Human WB, IHC (p), FACS Wirt: Kaninchen Polyclonal RB20468 unconjugated
Produktnummer ABIN652514
  • Target Alle BRISC and BRCA1 A Complex Member 1 (BABAM1) Antikörper anzeigen
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Bindungsspezifität
    • 10
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 116-143
    Reaktivität
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 21
    • 4
    • 1
    Kaninchen
    Klonalität
    • 24
    • 2
    Polyklonal
    Konjugat
    • 16
    • 2
    • 2
    • 2
    • 2
    • 2
    Unkonjugiert
    Applikation
    • 23
    • 16
    • 13
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Homologie
    B, M, Rat
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-143 amino acids from the Central region of human HSPC142.
    Klon
    RB20468
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    BRISC and BRCA1 A Complex Member 1 (BABAM1)
    Andere Bezeichnung
    HSPC142 (BABAM1 Produkte)
    Synonyme
    merit40 antikoerper, nba1 antikoerper, zgc:100909 antikoerper, c19orf62 antikoerper, C19orf62 antikoerper, MERIT40 antikoerper, NBA1 antikoerper, C7H19orf62 antikoerper, 5430437P03Rik antikoerper, Merit40 antikoerper, BRISC and BRCA1 A complex member 1 antikoerper, BRISC and BRCA1 A complex member 1 L homeolog antikoerper, babam1 antikoerper, BABAM1 antikoerper, babam1.L antikoerper, Babam1 antikoerper
    Hintergrund
    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
    Molekulargewicht
    36560
    Gen-ID
    29086
    NCBI Accession
    NP_001028721, NP_054892
    UniProt
    Q9NWV8
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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