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NLRP3 Antikörper (N-Term)

NLRP3 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB22404 unconjugated
Produktnummer ABIN652504
  • Target Alle NLRP3 Antikörper anzeigen
    NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
    Bindungsspezifität
    • 16
    • 9
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 65-91, N-Term
    Reaktivität
    • 91
    • 57
    • 38
    • 23
    • 4
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 87
    • 11
    • 2
    • 1
    Kaninchen
    Klonalität
    • 85
    • 16
    Polyklonal
    Konjugat
    • 44
    • 9
    • 8
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser NLRP3 Antikörper ist unkonjugiert
    Applikation
    • 63
    • 40
    • 22
    • 13
    • 13
    • 10
    • 9
    • 9
    • 7
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This NLRP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human NLRP3.
    Klon
    RB22404
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product NLRP3 Primärantikörper
  • Applikationshinweise
    WB: 1:1000-1:2000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Liu, Wen, Chen, Wang, Huang, Tu: "Effects of Berberine on NLRP3 and IL-1β Expressions in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation." in: BioMed research international, Vol. 2016, pp. 2503703, (2016) (PubMed).

    Jhang, Lu, Ho, Cheng, Yen: "Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation." in: Journal of agricultural and food chemistry, (2015) (PubMed).

    Liu, Tu, Chen, Wang, Hu, Dong: "Effects of Modified Simiao Decoction on IL-1 β and TNF α Secretion in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 406816, (2014) (PubMed).

  • Target
    NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
    Andere Bezeichnung
    NLRP3 (NLRP3 Produkte)
    Synonyme
    CIAS1 antikoerper, Nalp3 antikoerper, avp antikoerper, cias1 antikoerper, nalp3 antikoerper, pypaf1 antikoerper, agtavprl antikoerper, AGTAVPRL antikoerper, AII antikoerper, AVP antikoerper, C1orf7 antikoerper, CLR1.1 antikoerper, FCAS antikoerper, FCU antikoerper, MWS antikoerper, NALP3 antikoerper, PYPAF1 antikoerper, AII/AVP antikoerper, Cias1 antikoerper, Mmig1 antikoerper, Pypaf1 antikoerper, NLR family pyrin domain containing-like antikoerper, NLR family pyrin domain containing 3 antikoerper, NLR family, pyrin domain containing 3 L homeolog antikoerper, NLR family, pyrin domain containing 3 antikoerper, NLRPL antikoerper, NLRP3 antikoerper, nlrp3.L antikoerper, Nlrp3 antikoerper
    Hintergrund
    NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis.
    Molekulargewicht
    118173
    Gen-ID
    114548
    NCBI Accession
    NP_001073289, NP_001120933, NP_001120934, NP_001230062, NP_004886, NP_899632
    UniProt
    Q96P20
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome
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