GNE Antikörper (Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase) (AA 580-607)

Details for Product anti-GNE Antibody No. ABIN651511, Anbieter: Anmelden zum Anzeigen
Antigen
  • DMRV
  • GLCNE
  • IBM2
  • UAE1
  • zgc:77657
  • GNE
  • MGC145505
  • NM
  • Uae1
  • 2310066H07Rik
  • glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
  • GNE
  • gne
  • Gne
Epitop
AA 580-607, C-Term
10
10
9
9
8
8
3
2
1
1
1
Reaktivität
Human, Maus
61
32
23
Wirt
Kaninchen
60
1
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser GNE Antikörper ist unkonjugiert
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Western Blotting (WB)
49
34
21
15
13
7
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 580-607 AA from the C-terminal region of human GNE.
Klon RB26213
Isotyp Ig
Spezifität This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-618 amino acids from the C-terminal region of human GNE.
Homologie Hamster,Rat (Rattus)
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung GNE (GNE Antibody Abstract)
Hintergrund GNE is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells.
Synonyms: ManAc kinase, N-acetylmannosamine kinase, UDP-GlcNAc-2-epimerase, Uridine diphosphate-N-acetylglucosamine-2-epimerase, UDP-N-acetylglucosamine 2-epimerase, UDP-GlcNAc-2-epimerase/ManAc kinase, Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase,GLCNE, GNE
Molekulargewicht 79275 DA
Gen-ID 10020
NCBI Accession NP_005467
UniProt Q9Y223
Forschungsgebiet Phospho-specific antibodies, Protein Modifications, Chromatin, Signaling, Cell Structure
Applikationshinweise WB = 1:1000, FACS = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) (AA 580-607), (C-Term) antibody (ABIN651511) GNE Antibody (C-term) (ABIN651511) western blot analysis in mouse kidney tissue lysat...
Flow Cytometry (FACS) image for anti-Glucosamine (UDP-N-Acetyl)-2-Epimerase/N-Acetylmannosamine Kinase (GNE) (AA 580-607), (C-Term) antibody (ABIN651511) GNE Antibody (C-term) (ABIN651511) flow cytometric analysis of Jurkat cells (right hi...
Allgemeine Veröffentlichungen Klootwijk, Savelkoul, Ciccone, Manoli, Caplen, Krasnewich, Gahl, Huizing: "Allele-specific silencing of the dominant disease allele in sialuria by RNA interference." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 22, Issue 11, pp. 3846-52, 2008 (PubMed).

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