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Huntingtin (HTT) Antikörper
| Antigen | Huntingtin (HTT) |
| Synonyme | HD, IT15, Hd, Hdh, AI256365, C430023I11Rik, hd, ZHD, HTT, HsapHD, dhtt, DmelCG9995, CG9995, Htt, HDH, SLC6A4, it15, MGC79590, htt, LOC100216476 |
| Wirt |
 Alternativen Maus |
| Reaktivität |
Alternativen Human |
| Applikation |
Alternativen ELISA, Western Blot (WB), Immunhistochemie (Paraffinschnitte) (IHC (p)), Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunpräzipitation (IP)
|
| Produktnummer | ABIN640813 |
| Menge | 0.1 ml (IgG concentration 1.0 mg/ml) (Varianten) |
| Preis | 1.430,77 € Zzgl. Versandkosten €20,00 und MWSt |
| Lieferung nach |
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| Verfügbarkeit | Lieferung in 5 bis 7 Werktagen |
Produktbeschreibung
| Produktmerkmale | Mouse Anti-Human Huntingtin |
| Weitere Bezeichnung | Huntingtin |
| Immunogen | Huntington fragment from amino acids 181 - 810 as a fusion protein. |
| Kreuzreaktivität | Maus, Hamster, Affe, Ratte (Rattus) |
| Format | Ascites |
| Isotyp | IgG1 (Passende Sekundärantikörper) |
| Beschreibung | Synonyms: IT15 |
| Spezifität | DS-MB-01571 is specific for Huntingtin protein and reacts with an epitope between amino acids 181 and 810. A band of approximately 350-400 kDa is observed in Western blotting. Huntingtin is found in the perinuclear region along with microtubules, and in the centrosomal region along with gamma-tubulin. It is necessary for neuronal survival and is involved in synaptic vesicle trafficking, microtubule binding and may also have a role in apoptosis. In huntington disease, neuronal cells with the mutant form of huntingtin possess intranuclear aggregations of the N-terminal fragment, causing damaging inclusions in perinuclear locations and striatal neuron cell death. Wild-type huntington and anti-huntingtin reduce aggregation and cellular toxicity of the mutant huntingtin form in mammalian cell models of HD. Huntingtin is known to interact with GAPDH, HAP-1, SP1 and TAFII130. |
Anwendungen
| Konzentration | IgG concentration 1.0 mg/ml |
| Lagerung | Store at -20 ° C only. |
| Forschungsgebiet | Neurologie, Virologie |
| Beschränkungen | Nur für Forschungszwecke einsetzbar |
Alternativen
Alternativen zu Antigen "Huntingtin (HTT)", Typ "Antikörper" finden
| Wirte | Maus (30), Kaninchen (12) |
| Reaktivitäten | Human (37), Maus (16), Ratte (Rattus) (11), Kaninchen (3), Huhn (1), Rind (Kuh) (1), Hund (1), Affe (1) |
| Applikationen | Western Blot (WB) (41), Enzyme Immunoassay (EIA) (17), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (15), Immunpräzipitation (IP) (13), Immunhistochemie (IHC) (5), Immunhistochemie (Paraffinschnitte) (IHC (p)) (5), ELISA (3), Immunfluoreszenz (IF) (3), Durchflusszytometrie (FACS) (2), Dot Blot (Dot) (1), Immunzytochemie (ICC) (1) |
| Epitope | pSer421 (4), internal (2), AA 1844-2131 (1), AA 2703-2911 (1), AA 997-1276 (1), C-Term (1), pS421 (1) |
