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CD3 Antikörper

CD3 Reaktivität: Human, Affe FACS, IP, IHC (fro), Func Wirt: Maus Monoclonal UCHT1 unconjugated
Produktnummer ABIN616760
  • Target Alle CD3 Antikörper anzeigen
    CD3
    Reaktivität
    • 222
    • 97
    • 31
    • 15
    • 15
    • 9
    • 8
    • 8
    • 7
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    Human, Affe
    Wirt
    • 257
    • 52
    • 14
    • 13
    • 10
    Maus
    Klonalität
    • 334
    • 8
    Monoklonal
    Konjugat
    • 97
    • 36
    • 32
    • 26
    • 24
    • 13
    • 9
    • 9
    • 9
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD3 Antikörper ist unkonjugiert
    Applikation
    • 294
    • 92
    • 58
    • 52
    • 45
    • 44
    • 39
    • 24
    • 16
    • 10
    • 9
    • 9
    • 9
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
    Spezifität
    This antibody recognizes the CD3 antigen of the TCR/CD3 complex on mature Human T cells. The UCHT1 antibody reacts with the epsilon chain of the CD3 complex.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Non-Human Primates.
    Aufreinigung
    Protein-A Affinity Chromatography
    Immunogen
    Human thymocytes followed by Sezary T cells.
    Klon
    UCHT1
    Isotyp
    IgG1
    Top Product
    Discover our top product CD3 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Azide Free phosphate buffered saline (PBS), pH ~7.4 and 0.2 μm filter sterilized
    Konservierungsmittel
    Azide free
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CD3
    Andere Bezeichnung
    CD3 (CD3 Produkte)
    Synonyme
    CD3 antikoerper, AI504783 antikoerper, CD3epsilon antikoerper, T3e antikoerper, cd3-gamma antikoerper, cd3g antikoerper, cd3g-a antikoerper, cd3g/d antikoerper, cd3gd antikoerper, t3g antikoerper, CD3e molecule antikoerper, CD3d molecule antikoerper, CD3 antigen, epsilon polypeptide antikoerper, CD3g molecule S homeolog antikoerper, CD3E antikoerper, CD3D antikoerper, Cd3e antikoerper, cd3g.S antikoerper
    Hintergrund
    CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82 % of normal peripheral blood lymphocytes, 65-85 % of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.Synonyms: T-cell surface antigen T3/Leu-4, T-cell surface glycoprotein CD3, T3/Leu-4
    Gen-ID
    916
    NCBI Accession
    NP_000724
    UniProt
    P07766
    Pathways
    T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway
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