IGF1R Antikörper (pTyr1280)

Produktnummer ABIN616037

Produktdetails anti-IGF1R Antikörper

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Bindungsspezifität: pTyr1280

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IGF1R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1280.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity-chromatography using epitope-specific peptide

Immunogen: Peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y(p)-Y-S) derived from Human IGF-1R

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Andere Bezeichnung: CD221 / IGF1R (IGF1R Produkte)

Synonyme: CMT2N antikoerper, CD221 antikoerper, IGFIR antikoerper, IGFR antikoerper, JTK13 antikoerper, IGFIRC antikoerper, IGFR1 antikoerper, IGF-1R antikoerper, IGF1R antikoerper, DKFZp469I0618 antikoerper, igf-1r antikoerper, xIGF-1R antikoerper, xIGFR antikoerper, xigf1r antikoerper, A330103N21Rik antikoerper, D930020L01 antikoerper, hyft antikoerper, igf-ir antikoerper, IGF-IR antikoerper, IGF-IRb antikoerper, wu:fb03h06 antikoerper, IGF-IRa antikoerper, sb:eu1090 antikoerper, wu:fi20b10 antikoerper, alanyl-tRNA synthetase antikoerper, insulin like growth factor 1 receptor antikoerper, insulin-like growth factor 1 receptor antikoerper, insulin-like growth factor 1 antikoerper, insulin-like growth factor I receptor antikoerper, insulin like growth factor 1 receptor S homeolog antikoerper, insulin-like growth factor 1b receptor antikoerper, insulin-like growth factor 1a receptor antikoerper, AARS antikoerper, IGF1R antikoerper, Igf1r antikoerper, igf1r antikoerper, Igf1 antikoerper, LOC780503 antikoerper, LOC100136427 antikoerper, igf1r.S antikoerper, igf1rb antikoerper, igf1ra antikoerper

Hintergrund: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.Synonyms: IGF-I receptor, IGF1 Receptor, Insulin-like growth factor 1 receptor

Gen-ID: 3480

NCBI Accession: NP_000866

UniProt: P08069

Pathways: RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie