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HAP1 Antikörper (C-Term)

HAP1 Reaktivität: Maus, Ratte WB, EIA Wirt: Ziege Polyclonal unconjugated
Produktnummer ABIN615992
  • Target Alle HAP1 Antikörper anzeigen
    HAP1 (Huntingtin Associated Protein 1 (HAP1))
    Bindungsspezifität
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 13
    • 6
    • 5
    Maus, Ratte
    Wirt
    • 12
    • 4
    • 2
    Ziege
    Klonalität
    • 15
    • 3
    Polyklonal
    Konjugat
    • 15
    • 1
    • 1
    • 1
    Dieser HAP1 Antikörper ist unkonjugiert
    Applikation
    • 14
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Sequenz
    C-QDAHSKRQQK QK
    Spezifität
    Recognizes Mouse Hap1
    Kreuzreaktivität (Details)
    Species reactivity (expected):Rat.
    Species reactivity (tested):Mouse.
    Aufreinigung
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
    Immunogen
    Peptide with sequence from the C Terminus of the protein sequence according to NP_034534.1. Genename: Hap1
    Top Product
    Discover our top product HAP1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    HAP1 (Huntingtin Associated Protein 1 (HAP1))
    Andere Bezeichnung
    HAP1 (HAP1 Produkte)
    Synonyme
    HAP2 antikoerper, HIP5 antikoerper, HLP antikoerper, hHLP1 antikoerper, HAP1-A antikoerper, HAP1-B antikoerper, HAP-1 antikoerper, huntingtin associated protein 1 antikoerper, huntingtin-associated protein 1 antikoerper, HAP1 antikoerper, Hap1 antikoerper
    Hintergrund
    Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. It is a progressive disorder that generally begins in middle age with abnormalities of movement, cognition, personality and mood. HAP-1 is highly expressed in brain and shown to mediate the neuropathology of HD. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified but one is a nonsense-mediated decay (NMD) candidate.Synonyms: HAP-1, HAP2, HLP1, Huntingtin-associated protein 1, Neuroan 1
    Gen-ID
    15114
    NCBI Accession
    NP_034534
    UniProt
    O35668
    Pathways
    Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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