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CD8B Antikörper

CD8B Reaktivität: Ratte FACS, WB, IP, IHC (fro) Wirt: Maus Monoclonal 341 unconjugated
Produktnummer ABIN609653
  • Target Alle CD8B Antikörper anzeigen
    CD8B (CD8b Molecule (CD8B))
    Reaktivität
    • 74
    • 38
    • 22
    • 13
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 77
    • 38
    • 28
    Maus
    Klonalität
    • 78
    • 64
    • 1
    Monoklonal
    Konjugat
    • 59
    • 17
    • 16
    • 13
    • 8
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD8B Antikörper ist unkonjugiert
    Applikation
    • 78
    • 77
    • 45
    • 24
    • 16
    • 15
    • 13
    • 13
    • 10
    • 7
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    The mouse monoclonal antibody 341 (also known as 34.1) recognizes rat CD8b, the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope), expressed on T cell subsets and some other cell types, such as macrophages.
    Kreuzreaktivität (Details)
    Rat
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    CD8 positive Wistar rat splenic T cell hybridomas
    Klon
    341
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product CD8B Primärantikörper
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 1.5 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Rossi, Del Principe, Rossi, Irno Consalvo, Luciano, Zucchetto, Bulian, Bomben, Dal Bo, Fangazio, Benedetti, Degan, Gaidano, Del Poeta, Gattei: "Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells." in: Journal of translational medicine, Vol. 8, pp. 23, (2010) (PubMed).

    Vroblova, Vrbacky, Hrudkova, Jankovicova, Schmitzova, Maly, Krejsek, Smolej: "Significant change in ZAP-70 expression during the course of chronic lymphocytic leukemia." in: European journal of haematology, Vol. 84, Issue 6, pp. 513-7, (2010) (PubMed).

    Mabarrack, Turner, Mayrhofer: "Recent thymic origin, differentiation, and turnover of regulatory T cells." in: Journal of leukocyte biology, Vol. 84, Issue 5, pp. 1287-97, (2008) (PubMed).

    Nohara, Kulka, Déry, Wills, Hirji, Gilchrist, Befus: "Regulation of CD8 expression in mast cells by exogenous or endogenous nitric oxide." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 10, pp. 5935-9, (2001) (PubMed).

    Ellerman, Like: "Islet cell membrane antigens activate diabetogenic CD4+ T-cells in the BB/Wor rat." in: Diabetes, Vol. 48, Issue 5, pp. 975-82, (1999) (PubMed).

    Lin, Hirji, Nohara, Stenton, Gilchrist, Befus: "Mast cells express novel CD8 molecules that selectively modulate mediator secretion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 6265-72, (1998) (PubMed).

    Kraus, Lambracht, Wonigeit, Hünig: "Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition." in: European journal of immunology, Vol. 26, Issue 11, pp. 2582-6, (1997) (PubMed).

    Hirji, Lin, Befus: "A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 4, pp. 1833-40, (1997) (PubMed).

    Torres-Nagel, Kraus, Brown, Tiefenthaler, Mitnacht, Williams, Hünig: "Differential thymus dependence of rat CD8 isoform expression." in: European journal of immunology, Vol. 22, Issue 11, pp. 2841-8, (1992) (PubMed).

  • Target
    CD8B (CD8b Molecule (CD8B))
    Andere Bezeichnung
    CD8b (CD8B Produkte)
    Synonyme
    Cd8b antikoerper, Ly-3 antikoerper, Ly-C antikoerper, Lyt-3 antikoerper, CD8B1 antikoerper, LEU2 antikoerper, LY3 antikoerper, LYT3 antikoerper, P37 antikoerper, Cd8b1 antikoerper, CD8b molecule antikoerper, CD8 antigen, beta chain 1 antikoerper, Cd8b antikoerper, CD8B antikoerper, Cd8b1 antikoerper
    Hintergrund
    CD8b molecule,The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages, mast cells, and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.,Ly-3, Ly-C, Lyt-3
    Gen-ID
    926
    UniProt
    P10966
    Pathways
    T-Zell Rezeptor Signalweg
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