G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) (C-Term) Antikörper

Antigen: G Protein-Coupled Bile Acid Receptor 1 (GPBAR1)

Synonyme: BG37, GPCR, TGR5, M-BAR, GPCR19, GPR131, MGC40597, GPBAR1, MGC152072, Tgr5, MGC84403, Gpbar1

Epitope: C-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN572218

Produktbeschreibung

Weitere Bezeichnung: GPCR TGR5 (GPBAR1) (c-terminal region)

Format: Lyophilized

Beschreibung: FUNCTION: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum. Subcellular location: Cell membrane; Multi-pass membrane protein Also known as: GPBAR, GPBAR1, Membrane-type receptor for bile acids, M-BAR, Tgr5, G protein coupled bile acid receptor 1.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar