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CD80 Antikörper

CD80 Reaktivität: Maus, Hund FACS, IP, IHC (fro), Func Wirt: Hamster Monoclonal 16-10A1 unconjugated
Produktnummer ABIN567985
  • Target Alle CD80 Antikörper anzeigen
    CD80
    Reaktivität
    • 139
    • 123
    • 44
    • 8
    • 3
    • 3
    • 1
    • 1
    • 1
    Maus, Hund
    Wirt
    • 88
    • 71
    • 26
    • 24
    • 23
    • 1
    • 1
    Hamster
    Klonalität
    • 154
    • 77
    • 2
    Monoklonal
    Konjugat
    • 90
    • 20
    • 19
    • 17
    • 15
    • 6
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    • 5
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    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD80 Antikörper ist unkonjugiert
    Applikation
    • 141
    • 94
    • 70
    • 41
    • 34
    • 22
    • 14
    • 14
    • 13
    • 13
    • 12
    • 11
    • 11
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
    Spezifität
    This Hamster antibody reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Mouse, Canine (Dog).
    Aufreinigung
    Protein-A affinity chromatography
    Immunogen
    CD80-transfected CHO cell line
    Klon
    16-10A1
    Isotyp
    IgG2
    Top Product
    Discover our top product CD80 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.4 with 15 mM Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Mukherjee, Ahmed, Malu, Nandi: "Modulation of cell cycle progression by CTLA4-CD80/CD86 interactions on CD4+ T cells depends on strength of the CD3 signal: critical role for IL-2." in: Journal of leukocyte biology, Vol. 80, Issue 1, pp. 66-74, (2006) (PubMed).

    Odobasic, Kitching, Semple, Timoshanko, Tipping, Holdsworth: "Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis." in: Journal of the American Society of Nephrology : JASN, Vol. 16, Issue 7, pp. 2012-22, (2005) (PubMed).

    Huet, Bagot, Loyaux, Capdevielle, Conraux, Ferrara, Bensussan, Marie-Cardine: "SC5 mAb represents a unique tool for the detection of extracellular vimentin as a specific marker of Sezary cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 1, pp. 652-9, (2005) (PubMed).

    Paust, Lu, McCarty, Cantor: "Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10398-403, (2004) (PubMed).

    Reiser, von Gersdorff, Loos, Oh, Asanuma, Giardino, Rastaldi, Calvaresi, Watanabe, Schwarz, Faul, Kretzler, Davidson, Sugimoto, Kalluri, Sharpe, Kreidberg, Mundel: "Induction of B7-1 in podocytes is associated with nephrotic syndrome." in: The Journal of clinical investigation, Vol. 113, Issue 10, pp. 1390-7, (2004) (PubMed).

    Quah, Ni, ONeill: "In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity." in: International immunology, Vol. 16, Issue 4, pp. 567-77, (2004) (PubMed).

    Mencacci, Montagnoli, Bacci, Cenci, Pitzurra, Spreca, Kopf, Sharpe, Romani: "CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 6, pp. 3180-90, (2002) (PubMed).

    Horspool, Perrin, Woodcock, Cox, King, June, Harlan, St Louis, Lee: "Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 6, pp. 2706-14, (1998) (PubMed).

  • Target
    CD80
    Andere Bezeichnung
    CD80 (CD80 Produkte)
    Synonyme
    B7 antikoerper, B7-1 antikoerper, B7.1 antikoerper, BB1 antikoerper, CD28LG antikoerper, CD28LG1 antikoerper, LAB7 antikoerper, B71 antikoerper, Cd28l antikoerper, Ly-53 antikoerper, Ly53 antikoerper, MIC17 antikoerper, TSA1 antikoerper, CD80 molecule antikoerper, Cd80 molecule antikoerper, CD80 antigen antikoerper, CD80 antikoerper, Cd80 antikoerper
    Hintergrund
    CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 Molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet, there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.Synonyms: Activation B7-1 antigen, B7-1, B7.1, BB1, CD28LG, CD28LG1, CTLA-4 counter-receptor B7.1, LAB7, T-lymphocyte activation antigen CD80
    Gen-ID
    12519
    NCBI Accession
    NP_033985
    UniProt
    Q00609
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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