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TARDBP Antikörper (AA 1-260)

TARDBP Reaktivität: Human WB, ELISA, IF, IP, IHC (p), RNAi Wirt: Maus Monoclonal 2E2-D3 unconjugated
Produktnummer ABIN565080
  • Target Alle TARDBP Antikörper anzeigen
    TARDBP (TAR DNA Binding Protein (TARDBP))
    Bindungsspezifität
    • 15
    • 12
    • 11
    • 9
    • 7
    • 7
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-260
    Reaktivität
    • 100
    • 59
    • 59
    • 13
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 103
    • 13
    • 1
    Maus
    Klonalität
    • 94
    • 23
    Monoklonal
    Konjugat
    • 64
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TARDBP Antikörper ist unkonjugiert
    Applikation
    • 85
    • 47
    • 33
    • 31
    • 20
    • 17
    • 14
    • 13
    • 13
    • 7
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)
    Verwendungszweck
    Mouse monoclonal antibody raised against a partial recombinant TARDBP.
    Sequenz
    MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA
    Kreuzreaktivität
    Human
    Produktmerkmale
    Antibody Reactive Against Recombinant Protein.
    Immunogen
    TARDBP (NP_031401.1, 1 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Klon
    2E2-D3
    Isotyp
    IgG1
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    In 1x PBS, pH 7.4
    Handhabung
    Aliquot to avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Lynch, Jaunmuktane, Sheerin, Phadke, Brandner, Milonas, Dean, Bajaj, McNicholas, Costello, Cronin, McGuigan, Rossor, Fox, Murphy, Chataway, Houlden: "Hereditary leukoencephalopathy with axonal spheroids: a spectrum of phenotypes from CNS vasculitis to parkinsonism in an adult onset leukodystrophy series." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 87, Issue 5, pp. 512-9, (2016) (PubMed).

    De Marco, Lomartire, Calvo, Risso, De Luca, Mostert, Mandrioli, Caponnetto, Borghero, Manera, Canosa, Moglia, Restagno, Fini, Tarella, Giordana, Rinaudo, Chiò: "Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution." in: Neuropathology and applied neurobiology, Vol. 43, Issue 2, pp. 133-153, (2016) (PubMed).

    Gelpi, Höftberger, Graus, Ling, Holton, Dawson, Popovic, Pretnar-Oblak, Högl, Schmutzhard, Poewe, Ricken, Santamaria, Dalmau, Budka, Revesz, Kovacs: "Neuropathological criteria of anti-IgLON5-related tauopathy." in: Acta neuropathologica, Vol. 132, Issue 4, pp. 531-43, (2016) (PubMed).

    Rosenbohm, Buckert, Gerischer, Walcher, Kassubek, Rottbauer, Ludolph, Bernhardt: "Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography." in: Journal of neurology, Vol. 262, Issue 4, pp. 949-56, (2015) (PubMed).

    Iovino, Pfisterer, Holton, Lashley, Swingler, Calo, Treacy, Revesz, Parmar, Goedert, Muqit, Spillantini: "The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons." in: Acta neuropathologica, Vol. 127, Issue 2, pp. 283-95, (2014) (PubMed).

    Hebron, Chen, Miessau, Lonskaya, Moussa: "Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis." in: Journal of neurochemistry, Vol. 129, Issue 2, pp. 350-61, (2014) (PubMed).

    Suárez-Calvet, Dols-Icardo, Lladó, Sánchez-Valle, Hernández, Amer, Antón-Aguirre, Alcolea, Fortea, Ferrer, van der Zee, Dillen, Van Broeckhoven, Molinuevo, Blesa, Clarimón, Lleó: "Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 85, Issue 6, pp. 684-91, (2014) (PubMed).

    Yan, Wang, Wei, Gaertig, Lai, Li, Li: "TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain." in: Human molecular genetics, Vol. 23, Issue 10, pp. 2678-93, (2014) (PubMed).

    De Marco, Lomartire, Mandili, Lupino, Buccinnà, Ramondetti, Moglia, Novelli, Piccinini, Mostert, Rinaudo, Chiò, Calvo: "Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 725-34, (2014) (PubMed).

    Cortese, Plagnol, Brady, Simone, Lashley, Acevedo-Arozena, de Silva, Greensmith, Holton, Hanna, Fisher, Fratta: "Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy." in: Neurobiology of aging, Vol. 35, Issue 6, pp. 1491-8, (2014) (PubMed).

    Ohta, Tremblay, Schneider, Bennett, Calon, Julien: "Interaction of transactive response DNA binding protein 43 with nuclear factor ?B in mild cognitive impairment with episodic memory deficits." in: Acta neuropathologica communications, Vol. 2, Issue 1, pp. 37, (2014) (PubMed).

    Gelpi, Navarro-Otano, Tolosa, Gaig, Compta, Rey, Martí, Hernández, Valldeoriola, Reñé, Ribalta: "Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, Issue 8, pp. 1010-8, (2014) (PubMed).

    Carlomagno, Zhang, Davis, Lin, Cook, Dunmore, Tay, Menkosky, Cao, Petrucelli, Deture: "Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins." in: PLoS ONE, Vol. 9, Issue 3, pp. e90452, (2014) (PubMed).

    Kara, Kiely, Proukakis, Giffin, Love, Hehir, Rantell, Pandraud, Hernandez, Nacheva, Pittman, Nalls, Singleton, Revesz, Bhatia, Quinn, Hardy, Holton, Houlden: "A 6.4 Mb duplication of the ?-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations." in: JAMA neurology, Vol. 71, Issue 9, pp. 1162-71, (2014) (PubMed).

    Balasa, Gelpi, Rey, Vila, Ramió-Torrentà, Quiles Granado, Molina Latorre, Lepidi, Raoult, Saiz: "Clinical and neuropathological variability in clinically isolated central nervous system Whipple's disease." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 3, pp. 230-8, (2014) (PubMed).

    Araki, Minegishi, Motoki, Kume, Hohjoh, Araki, Tamaoka: "Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway." in: Molecular neurobiology, Vol. 50, Issue 3, pp. 1049-58, (2014) (PubMed).

    Hans, Fiesel, Strong, Jäckel, Rasse, Geisler, Springer, Schulz, Voigt, Kahle: "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19164-79, (2014) (PubMed).

    Robinson, Thompson, Weedon, Rollinson, Pickering-Brown, Snowden, Davidson, Mann: "No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease." in: Neuropathology and applied neurobiology, Vol. 40, Issue 7, pp. 844-54, (2014) (PubMed).

    Alafuzoff, Pikkarainen, Neumann, Arzberger, Al-Sarraj, Bodi, Bogdanovic, Bugiani, Ferrer, Gelpi, Gentleman, Giaccone, Graeber, Hortobagyi, Ince, Ironside, Kavantzas, King, Korkolopoulou, Kovács et al.: "Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. ..." in: Journal of neural transmission (Vienna, Austria : 1996), (2014) (PubMed).

    Wenqiang, Lonskaya, Hebron, Ibrahim, Olszewski, Neale, Moussa: "Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice." in: Human molecular genetics, Vol. 23, Issue 18, pp. 4960-9, (2014) (PubMed).

  • Target
    TARDBP (TAR DNA Binding Protein (TARDBP))
    Andere Bezeichnung
    TARDBP (TARDBP Produkte)
    Synonyme
    TARDBP antikoerper, TDP43 antikoerper, DKFZp459I2127 antikoerper, tardbp antikoerper, ALS10 antikoerper, TDP-43 antikoerper, 1190002A23Rik antikoerper, C85084 antikoerper, Tdp43 antikoerper, wu:fb77f02 antikoerper, wu:fc52g10 antikoerper, TAR DNA binding protein antikoerper, Tardbp protein antikoerper, TAR DNA binding protein L homeolog antikoerper, TAR DNA-binding protein 43-like antikoerper, TARDBP antikoerper, tardbp antikoerper, tardbp.L antikoerper, Tardbp antikoerper, LOC100621383 antikoerper
    Hintergrund
    Full Gene Name: TAR DNA binding protein
    Synonyms: ALS10,TDP-43
    Gen-ID
    23435
    NCBI Accession
    NM_007375
    Pathways
    Positive Regulation of Peptide Hormone Secretion
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