CBFA2T2 Antikörper (N-Term)

Produktnummer ABIN951073

Produktdetails anti-CBFA2T2 Antikörper

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Bindungsspezifität: AA 1-30, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBFA2T2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to CBFA2T2.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CBFA2T2

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CBFA2T2

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Andere Bezeichnung: CBFA2T2 (CBFA2T2 Produkte)

Synonyme: MTGR1 antikoerper, A430091M07 antikoerper, C330013D05Rik antikoerper, Cbfa2t2h antikoerper, EHT antikoerper, ZMYND3 antikoerper, p85 antikoerper, XETOR antikoerper, cbfa2t2-a antikoerper, CBFA2/RUNX1 translocation partner 2 antikoerper, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) antikoerper, CBFA2/RUNX1 translocation partner 2 L homeolog antikoerper, Cbfa2t2 antikoerper, CBFA2T2 antikoerper, cbfa2t2.L antikoerper

Hintergrund: In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.Synonyms: EHT, ETO homologous on chromosome 20, MTG8-like protein, MTG8-related protein 1, MTGR1, Myeloid translocation-related protein 1, p85

Molekulargewicht: 67133 Da

Gen-ID: 9139

NCBI Accession: NP_001028171